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Mendeley readers
Attention Score in Context
| Title |
Development and Evaluation of a Novel Delivery System Containing Phytophospholipid Complex for Skin Aging
|
|---|---|
| Published in |
AAPS PharmSciTech, August 2015
|
| DOI | 10.1208/s12249-015-0386-x |
| Pubmed ID | |
| Authors |
Monica Damle, Rashmi Mallya |
| Abstract |
Citrus auranticum and Glycyrrhiza glabra are rich in anti-oxidant polyphenols helpful in prevention of skin aging. Polyphenols have high polarity and lower skin penetration resulting in lower cutaneous delivery. The present work is attempted to develop a novel polyherbal phospholipid complex cream to improve cutaneous delivery of polyphenols for sustained anti-oxidant action. Phytochemical and in vitro anti-oxidant evaluation was done on methanolic extracts of orange peel and liquorice powder. Total phenolic content, total flavonoid content, and anti-oxidant assays were done on different ratios of orange peel and liquorice extract. Ratio 1:2 gave highest total phenolic content (TPC) (530.00 ± 1.56 mg gallic acid equivalent (GAE) g(-1) extract), total flavonoid content (TFC) (246.25 ± 1.03 mg rutin equivalent (RUE) g(-1) extract), 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity (87.99 ± 0.64%), and H2O2 scavenging activity (72.47 ± 0.86%) and hence was used for formulation. Solvent evaporation method using methanol with 1:1 extract to phospholipid ratio was found to have entrapment efficiency of 93.22 ± 0.26%. Evaluation parameters like scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FT-IR), and differential scanning calorimetry (DSC) confirmed formation of complex. The complex was formulated as oil-in-water cream and evaluated for various parameters. The optimized cream containing 1% complex was non-irritant and was found to be stable for 3-month period under conditions of stability study. Ex vivo diffusion studies showed that extract phospholipid complex cream had better retention of polyphenols in the skin when compared to conventional extract cream giving prolonged and stronger topical action. The cream had an anti-elastase activity of 28.02 ± 0.95% at concentration of 3000 μg ml(-1) (w/v). Thus, the developed safe and stable polyherbal phytophospholipid complex cream exhibited good potential as anti-aging cosmeceutical. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| India | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 78 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 17% |
| Student > Master | 13 | 16% |
| Researcher | 9 | 11% |
| Student > Bachelor | 5 | 6% |
| Professor | 4 | 5% |
| Other | 12 | 15% |
| Unknown | 24 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 28% |
| Agricultural and Biological Sciences | 8 | 10% |
| Chemistry | 7 | 9% |
| Medicine and Dentistry | 5 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 31 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2015.
All research outputs
#20,288,585
of 22,824,164 outputs
Outputs from AAPS PharmSciTech
#1,332
of 1,468 outputs
Outputs of similar age
#223,067
of 265,958 outputs
Outputs of similar age from AAPS PharmSciTech
#40
of 41 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,468 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.