Title |
MUC1 (CD227): a multi-tasked molecule
|
---|---|
Published in |
Cellular and Molecular Life Sciences, August 2015
|
DOI | 10.1007/s00018-015-2014-z |
Pubmed ID | |
Authors |
Vasso Apostolopoulos, Lily Stojanovska, Sharron E. Gargosky |
Abstract |
Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule. |
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