miR-132 is also classified as a ‘neurimmiR’ b/c it is involved in the crosstalk between neurons and immune cells. Neurons secrete miR-132-containing EVs to regulate brain vascular integrity. And, protect against Dementia 12/21 https://t.co/8CJWXDI6Vt
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Interesting findings on the role of miRNA-132 on ameliorating #AlzheimersDisease. Enhanced expression and phosphorylation of CREB by specific kinases can increase miRNA-132 levels and promote neurogenesis. https://t.co/ZwKSJy4hZf
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MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways published as: https://t.co/sLwEI7dqPh #Acta_Neuropathologica #biorxiv
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#MicroRNAs regulieren biologische Prozesse, einschließlich neuronaler Plastizität, Stressreaktion und Überleben. MiR-132, ist in Neuronen bei der #Alzheimer-Krankheit am stärksten herunterreguliert, es schützt vor Amyloid β-P. und Glutamat-Excitotoxizität