Biaryl sulfonamide motifs up- or down-regulate ion channel activity by activating voltage sensors

Overview of attention for article published in Journal of General Physiology, July 2018

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Hot topic: Direct activation of neuronal KV7 channels by GABA and gabapentin – a novel mechanism for reducing neuronal excitability

guidetopharmacology blog, 30 Jul 2018

The potassium channels KV7.2-KV7.5 (KCNQ2-5; GtoPdb target IDs 561-564) regulate neuronal excitability in the mammalian nervous…

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