@kischober @PhilipAhern I always wondered if some of these T cells we pick via tetramers are not responsive to stimulation In a sense that the antigen here is an antagonist. https://t.co/sMYLoOJ63X
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New from #wellcometrust https://t.co/NMvedylluT Isolation and visualization of a structural trigger that uncouples TCR signaling from pMHC binding
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The question is, how often is this necessary? I think it’s the most powerful for learning basic biology about TCR-pMHC interactions, such as this example of discovering the role of catch bonds in TCR agonists: https://t.co/arHUf6ITnJ.
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https://t.co/c1S1mhqjtW "High-affinity but non-stimulatory T cell interactions occur in vivo"