Title |
Heritability of Brain Network Topology in 853 Twins and Siblings
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Published in |
2011 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, April 2015
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DOI | 10.1109/isbi.2015.7163908 |
Pubmed ID | |
Authors |
L. Zhan, N. Jahanshad, J. Faskowitz, D. Zhu, G. Prasad, N. G. Martin, G.I. de Zubicaray, K.L. McMahon, M.J. Wright, P.M. Thompson |
Abstract |
Anatomical brain networks change throughout life and with diseases. Genetic analysis of these networks may help identify processes giving rise to heritable brain disorders, but we do not yet know which network measures are promising for genetic analyses. Many factors affect the downstream results, such as the tractography algorithm used to define structural connectivity. We tested nine different tractography algorithms and four normalization methods to compute brain networks for 853 young healthy adults (twins and their siblings). We fitted genetic structural equation models to all nine network measures, after a normalization step to increase network consistency across tractography algorithms. Probabilistic tractography algorithms with global optimization (such as Probtrackx and Hough) yielded higher heritability statistics than "greedy" algorithms (such as FACT) which process small neighborhoods at each step. Some global network measures (probtrackx-derived GLOB and ST) showed significant genetic effects, making them attractive targets for genome-wide association studies. |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 25% |
Researcher | 2 | 17% |
Professor | 2 | 17% |
Student > Doctoral Student | 1 | 8% |
Student > Master | 1 | 8% |
Other | 1 | 8% |
Unknown | 2 | 17% |
Readers by discipline | Count | As % |
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Psychology | 2 | 17% |
Computer Science | 2 | 17% |
Environmental Science | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Mathematics | 1 | 8% |
Other | 2 | 17% |
Unknown | 3 | 25% |