Title |
Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors
|
---|---|
Published in |
Cell Reports, October 2015
|
DOI | 10.1016/j.celrep.2015.08.080 |
Pubmed ID | |
Authors |
Nurit Paz-Yaacov, Lily Bazak, Ilana Buchumenski, Hagit T. Porath, Miri Danan-Gotthold, Binyamin A. Knisbacher, Eli Eisenberg, Erez Y. Levanon |
Abstract |
Genomic mutations in key genes are known to drive tumorigenesis and have been the focus of much attention in recent years. However, genetic content also may change farther downstream. RNA editing alters the mRNA sequence from its genomic blueprint in a dynamic and flexible way. A few isolated cases of editing alterations in cancer have been reported previously. Here, we provide a transcriptome-wide characterization of RNA editing across hundreds of cancer samples from multiple cancer tissues, and we show that A-to-I editing and the enzymes mediating this modification are significantly altered, usually elevated, in most cancer types. Increased editing activity is found to be associated with patient survival. As is the case with somatic mutations in DNA, most of these newly introduced RNA mutations are likely passengers, but a few may serve as drivers that may be novel candidates for therapeutic and diagnostic purposes. |
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United States | 6 | 32% |
Sweden | 1 | 5% |
Germany | 1 | 5% |
Belgium | 1 | 5% |
Egypt | 1 | 5% |
United Kingdom | 1 | 5% |
Canada | 1 | 5% |
Unknown | 7 | 37% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 53% |
Scientists | 6 | 32% |
Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
Chile | 1 | <1% |
South Africa | 1 | <1% |
Norway | 1 | <1% |
Denmark | 1 | <1% |
Canada | 1 | <1% |
Unknown | 260 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 59 | 22% |
Researcher | 52 | 19% |
Student > Bachelor | 27 | 10% |
Student > Master | 26 | 10% |
Student > Doctoral Student | 10 | 4% |
Other | 31 | 12% |
Unknown | 63 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 88 | 33% |
Agricultural and Biological Sciences | 74 | 28% |
Medicine and Dentistry | 13 | 5% |
Computer Science | 6 | 2% |
Immunology and Microbiology | 5 | 2% |
Other | 14 | 5% |
Unknown | 68 | 25% |