Title |
Refining the Benefit/Risk Profile of Anti-Epileptic Drugs in Headache Disorders
|
---|---|
Published in |
CNS Drugs, August 2018
|
DOI | 10.1007/s40263-018-0555-z |
Pubmed ID | |
Authors |
Michael J. Marmura, Aliza S. Kumpinsky |
Abstract |
Anti-epileptic drugs are among the most effective drugs for migraine prophylaxis, and will likely continue to have a role even as new therapies emerge. Topiramate and valproate are effective for the preventive treatment of migraine, and other medications such as gabapentin or lamotrigine may have a role in the treatment of those with allodynia or frequent aura, respectively. Oxcarbazepine, carbamazepine, phenytoin, gabapentin, and others may alleviate pain in trigeminal neuralgia. While many anti-epileptic drugs can be effective in those with migraine or other headaches, most of these agents can potentially cause serious side effects. In particular, valproate, topiramate, carbamazepine, and phenytoin may lead to adverse outcomes for infants of exposed mothers. Valproate should not be given to women of childbearing potential for migraine prevention. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 12% |
Student > Ph. D. Student | 4 | 7% |
Student > Doctoral Student | 4 | 7% |
Student > Master | 4 | 7% |
Researcher | 3 | 5% |
Other | 9 | 16% |
Unknown | 27 | 47% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 29% |
Neuroscience | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Agricultural and Biological Sciences | 1 | 2% |
Psychology | 1 | 2% |
Other | 1 | 2% |
Unknown | 32 | 55% |