Title |
Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications
|
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Published in |
AORTA, July 2018
|
DOI | 10.1055/s-0038-1639612 |
Pubmed ID | |
Authors |
Adam J. Brownstein, Valentyna Kostiuk, Bulat A. Ziganshin, Mohammad A. Zafar, Helena Kuivaniemi, Simon C. Body, Allen E. Bale, John A. Elefteriades |
Abstract |
Thoracic aortic aneurysms, with an estimated prevalence in the general population of 1%, are potentially lethal, via rupture or dissection. Over the prior two decades, there has been an exponential increase in our understanding of the genetics of thoracic aortic aneurysm and/or dissection (TAAD). To date, 30 genes have been shown to be associated with the development of TAAD and ∼30% of individuals with nonsyndromic familial TAAD have a pathogenic mutation in one of these genes. This review represents the authors' yearly update summarizing the genes associated with TAAD, including implications for the surgical treatment of TAAD. Molecular genetics will continue to revolutionize the approach to patients afflicted with this devastating disease, permitting the application of genetically personalized aortic care. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 8 | 53% |
United Kingdom | 1 | 7% |
Luxembourg | 1 | 7% |
Unknown | 5 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 40% |
Practitioners (doctors, other healthcare professionals) | 5 | 33% |
Scientists | 4 | 27% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 16% |
Other | 5 | 11% |
Student > Postgraduate | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Student > Bachelor | 3 | 7% |
Other | 8 | 18% |
Unknown | 15 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 40% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Environmental Science | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Engineering | 1 | 2% |
Other | 0 | 0% |
Unknown | 19 | 42% |