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Sex of the baby and risk of gestational diabetes mellitus in the mother: a systematic review and meta-analysis

Overview of attention for article published in Diabetologia, August 2015
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Title
Sex of the baby and risk of gestational diabetes mellitus in the mother: a systematic review and meta-analysis
Published in
Diabetologia, August 2015
DOI 10.1007/s00125-015-3726-1
Pubmed ID
Authors

Diana Jaskolka, Ravi Retnakaran, Bernard Zinman, Caroline K. Kramer

Abstract

It has recently emerged that carrying a male fetus may be associated with poorer maternal beta cell function and an increased risk of gestational diabetes mellitus (GDM). Recognising that the overall impact of fetal sex on maternal glucose metabolism is likely to be subtle, we sought to perform a systematic review and meta-analysis of observational studies to obtain a robust estimate of the incremental maternal risk of GDM associated with the sex of the baby. We searched PubMed and EMBASE to identify observational studies published between 1 January 1950 and 4 April 2015 that reported data on fetal sex and the prevalence of GDM. Two independent reviewers extracted the data and pooled estimates of the RR were calculated by a random-effects model. We considered male fetus as the exposure and prevalence of GDM as the outcome of interest. We identified 320 studies through electronic searches and nine studies through manual searches. Twenty studies met the inclusion criteria, yielding data on 2,402,643 women. Pooled analysis of these studies demonstrated an increased risk of GDM in women carrying a male fetus compared with women carrying a female fetus (RR 1.04; 95% CI 1.02, 1.06). This result was confirmed in a sensitivity analysis including only studies that applied a stringent definition of GDM (RR 1.03; 95% CI 1.01, 1.06) (I (2) = 0%, p = 0.66). Pregnant women carrying a boy have a 4% higher relative risk of GDM than those carrying a girl. The fetus thus may have previously unsuspected effects on maternal glucose metabolism in pregnancy.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 16%
Student > Master 10 13%
Researcher 8 11%
Other 8 11%
Student > Bachelor 6 8%
Other 14 19%
Unknown 17 23%
Readers by discipline Count As %
Medicine and Dentistry 27 36%
Nursing and Health Professions 9 12%
Biochemistry, Genetics and Molecular Biology 5 7%
Neuroscience 2 3%
Immunology and Microbiology 2 3%
Other 4 5%
Unknown 26 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2016.
All research outputs
#15,332,207
of 23,577,761 outputs
Outputs from Diabetologia
#4,499
of 5,145 outputs
Outputs of similar age
#147,808
of 265,864 outputs
Outputs of similar age from Diabetologia
#44
of 71 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,145 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.3. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,864 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.