Title |
RNA interference to enhance radiation therapy: Targeting the DNA damage response
|
---|---|
Published in |
Cancer Letters, September 2018
|
DOI | 10.1016/j.canlet.2018.09.011 |
Pubmed ID | |
Authors |
G. Ratnayake, A.L. Bain, N. Fletcher, C.B. Howard, K.K. Khanna, K.J. Thurecht |
Abstract |
RNA interference (RNAi) therapy is an emerging class of biopharmaceutical that has immense potential in cancer medicine. RNAi medicines are based on synthetic oligonucleotides that can suppress a target protein in tumour cells with high specificity. This review explores the attractive prospect of using RNAi as a radiosensitizer by targeting the DNA damage response. There are a multitude of molecular targets involved in the detection and repair of DNA damage that are suitable for this purpose. Recent developments in delivery technologies such nanoparticle carriers and conjugation strategies have allowed RNAi therapeutics to enter clinical trials in the treatment of cancer. With further progress, RNAi targeting of the DNA damage response may hold great promise in guiding radiation oncology into the era of precision medicine. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 30% |
Student > Master | 4 | 17% |
Student > Ph. D. Student | 3 | 13% |
Researcher | 2 | 9% |
Other | 1 | 4% |
Other | 2 | 9% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 22% |
Biochemistry, Genetics and Molecular Biology | 5 | 22% |
Medicine and Dentistry | 3 | 13% |
Agricultural and Biological Sciences | 2 | 9% |
Energy | 1 | 4% |
Other | 1 | 4% |
Unknown | 6 | 26% |