Title |
Sublingual administration of atropine eyedrops in children with excessive drooling – a pilot study
|
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Published in |
International Journal of Paediatric Dentistry, December 2015
|
DOI | 10.1111/ipd.12219 |
Pubmed ID | |
Authors |
Johanna Norderyd, Jonas Graf, Agneta Marcusson, Karolina Nilsson, Eva Sjöstrand, Gunilla Steinwall, Elinor Ärleskog, Mats Bågesund |
Abstract |
Drooling can be a severe disability and have high impact on daily life. Reversible treatment is preferable. To analyse whether sublingual administration of atropine eyedrops is a useful reversible treatment option for severe drooling in children with disabilities. The study had a prospective, single-system research design. The participants served as their own controls. The study period was 3 weeks without treatment, 4 weeks with atropine eyedrop solution 10 mg/mL one drop a day followed by 4 weeks of one drop twice a day. Parents' rating of their child's drooling was assessed on a 100-mm VAS, and unstimulated salivary secretion rate measurement was performed together with notations about side effects and practicality. Parents' VAS assessment of drooling decreased from a median (range) of 74 (40-98) at baseline to 48 (18-88) (P = 0.05) and 32 (12-85) (P = 0.004) after 4 weeks of atropine once a day and another 4 weeks of atropine twice a day, respectively (n = 11). Unstimulated salivary secretion rates decreased from baseline to end of study (P = 0.032). Several parents complained about difficult administration. No irreversible side effects were noted. Sublingual atropine eyedrops may be an alternative for treatment of severe drooling in children with disabilities. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 16% |
Student > Postgraduate | 4 | 11% |
Student > Doctoral Student | 4 | 11% |
Student > Bachelor | 2 | 5% |
Professor | 2 | 5% |
Other | 9 | 24% |
Unknown | 11 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 53% |
Nursing and Health Professions | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Social Sciences | 2 | 5% |
Engineering | 1 | 3% |
Other | 0 | 0% |
Unknown | 10 | 26% |