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A Review of the Rationale for Additional Therapeutic Interventions to Attain Lower LDL-C When Statin Therapy Is Not Enough

Overview of attention for article published in Current Atherosclerosis Reports, November 2011
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Title
A Review of the Rationale for Additional Therapeutic Interventions to Attain Lower LDL-C When Statin Therapy Is Not Enough
Published in
Current Atherosclerosis Reports, November 2011
DOI 10.1007/s11883-011-0222-z
Pubmed ID
Authors

Jeffrey G. Shanes

Abstract

Statins alone are not always adequate therapy to achieve low-density lipoprotein (LDL) goals in many patients. Many options are available either alone or in combination with statins that makes it possible to reach recommended goals in a safe and tolerable fashion for most patients. Ezetimibe and bile acid sequestrants reduce cholesterol transport to the liver and can be used in combination. Niacin is very effective at lowering LDL, beyond its ability to raise high-density lipoprotein and shift LDL particle size to a less atherogenic type. When statins cannot be tolerated at all, red yeast rice can be used if proper formulations of the product are obtained. Nutrients can also be added to the diet, including plant stanols and sterols, soy protein, almonds, and fiber, either individually or all together as a portfolio diet. A clear understanding of how each of these strategies works is essential for effective results.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 55 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 20%
Student > Master 9 16%
Student > Ph. D. Student 8 14%
Other 7 13%
Student > Bachelor 5 9%
Other 8 14%
Unknown 8 14%
Readers by discipline Count As %
Medicine and Dentistry 25 45%
Agricultural and Biological Sciences 10 18%
Biochemistry, Genetics and Molecular Biology 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Environmental Science 1 2%
Other 5 9%
Unknown 10 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2019.
All research outputs
#20,152,153
of 22,659,164 outputs
Outputs from Current Atherosclerosis Reports
#705
of 762 outputs
Outputs of similar age
#217,777
of 239,467 outputs
Outputs of similar age from Current Atherosclerosis Reports
#7
of 7 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 762 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,467 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.