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Interactive effects of diabetes and impaired kidney function on cognitive performance in old age: a population-based study

Overview of attention for article published in BMC Geriatrics, January 2016
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Title
Interactive effects of diabetes and impaired kidney function on cognitive performance in old age: a population-based study
Published in
BMC Geriatrics, January 2016
DOI 10.1186/s12877-016-0193-6
Pubmed ID
Authors

Zhaoxue Yin, Zhongrui Yan, Yajun Liang, Hui Jiang, Chuanzhu Cai, Aiqin Song, Lei Feng, Chengxuan Qiu

Abstract

The interactive effect between diabetes and impaired kidney function on cognitive impairment in older adults has not yet been reported. The aim of this study was to investigate the association of diabetes and impaired kidney function with cognitive impairment among Chinese older people living in a rural area. This cross-sectional study included 1,358 participants (age ≥60 years; 60.5 % women) in the population-based Confucius Hometown Aging Project in Shandong, China. Data on demographics, lifestyle factors, health history, use of medications, global cognitive function, and kidney function were collected through structured interviews, clinical examinations, and blood tests. We defined diabetes as a fasting plasma glucose level ≥7.0 mmol/l or use of hypoglycemic agents, impaired kidney function as glomerular filtration rate estimated from cystatin C (eGFRcys) <60 ml/min/1.73 m(2). Cognitive impairment was defined using the education-based cut-off scores of Mini-Mental State Examination (MMSE). Data were analyzed using multiple general linear and logistic regression models. Cognitive impairment was defined in 197 (14.5 %) persons. The multi-adjusted β coefficient of MMSE score associated with diabetes was -0.06 (95 % confidence interval [CI], -0.16, 0.03); the corresponding figures associated with eGFRcys <60, 60-89.9, and ≥90 ml/min/1.73 m(2) were -0.15 (-0.28, -0.02), -0.01 (-0.10, 0.08), and 0 (reference) (P trend = 0.046), respectively. Diabetes and impaired kidney function showed an interactive effect on cognitive impairment (P interaction = 0.02). Compared with individuals having neither diabetes nor impaired kidney function, those with both conditions had a multi-adjusted odds ratio of 4.23 (95 % CI, 2.10-8.49) for cognitive impairment. The relative excess risk due to interaction was 2.74. This study suggests that concurrent presence of diabetes and impaired kidney function is associated with a substantial likelihood for cognitive impairment in older adults.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 50 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 16%
Student > Ph. D. Student 7 14%
Student > Bachelor 6 12%
Student > Postgraduate 6 12%
Other 5 10%
Other 9 18%
Unknown 10 20%
Readers by discipline Count As %
Medicine and Dentistry 13 25%
Nursing and Health Professions 10 20%
Psychology 10 20%
Neuroscience 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 3 6%
Unknown 10 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2016.
All research outputs
#18,434,182
of 22,837,982 outputs
Outputs from BMC Geriatrics
#2,633
of 3,189 outputs
Outputs of similar age
#285,487
of 395,128 outputs
Outputs of similar age from BMC Geriatrics
#56
of 66 outputs
Altmetric has tracked 22,837,982 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,189 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,128 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.