@nataliaduquew @DayLabUAB @SvitlanaBach @scharfmanlab But, you get a completely opposing phenotype if TrkB is depleted in some GABAergic populations - we have shown this, and also great work in this space from Prince lab at Stanford https://t.co/qkwhWn0DFG
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2,594 followers
This work followed up on previous work from our lab showing that TrkB depletion from cortistatin-expressing cells causes severe, spontaneous seizures that result in premature death https://t.co/S7xcF9x713
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Cortistatin-expressing interneurons require TrkB signaling to suppress neural hyper-excitability. https://t.co/pnanuXaOz0
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