Title |
Modelling cell lineage using a meta-Boolean tree model with a relation to gene regulatory networks
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Published in |
Journal of Theoretical Biology, October 2010
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DOI | 10.1016/j.jtbi.2010.10.003 |
Pubmed ID | |
Authors |
Jan-Åke Larsson, Niclas Wadströmer, Ola Hermanson, Urban Lendahl, Robert Forchheimer |
Abstract |
A cell lineage is the ancestral relationship between a group of cells that originate from a single founder cell. For example, in the embryo of the nematode Caenorhabditis elegans an invariant cell lineage has been traced, and with this information at hand it is possible to theoretically model the emergence of different cell types in the lineage, starting from the single fertilized egg. In this report we outline a modelling technique for cell lineage trees, which can be used for the C. elegans embryonic cell lineage but also extended to other lineages. The model takes into account both cell-intrinsic (transcription factor-based) and -extrinsic (extracellular) factors as well as synergies within and between these two types of factors. The model can faithfully recapitulate the entire C. elegans cell lineage, but is also general, i.e., it can be applied to describe any cell lineage. We show that synergy between factors, as well as the use of extrinsic factors, drastically reduce the number of regulatory factors needed for recapitulating the lineage. The model gives indications regarding co-variation of factors, number of involved genes and where in the cell lineage tree that asymmetry might be controlled by external influence. Furthermore, the model is able to emulate other (Boolean, discrete and differential-equation-based) models. As an example, we show that the model can be translated to the language of a previous linear sigmoid-limited concentration-based model (Geard and Wiles, 2005). This means that this latter model also can exhibit synergy effects, and also that the cumbersome iterative technique for parameter estimation previously used is no longer needed. In conclusion, the proposed model is general and simple to use, can be mapped onto other models to extend and simplify their use, and can also be used to indicate where synergy and external influence would reduce the complexity of the regulatory process. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 5% |
Sweden | 1 | 5% |
Unknown | 20 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 32% |
Researcher | 6 | 27% |
Student > Master | 4 | 18% |
Student > Bachelor | 1 | 5% |
Professor | 1 | 5% |
Other | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 55% |
Physics and Astronomy | 2 | 9% |
Philosophy | 1 | 5% |
Computer Science | 1 | 5% |
Mathematics | 1 | 5% |
Other | 5 | 23% |