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Mendeley readers
Attention Score in Context
| Title |
Dissection of the genetics of Parkinson's disease identifies an additional association 5′ of SNCA and multiple associated haplotypes at 17q21
|
|---|---|
| Published in |
Human Molecular Genetics, November 2010
|
| DOI | 10.1093/hmg/ddq469 |
| Pubmed ID | |
| Authors |
Chris C.A. Spencer, Vincent Plagnol, Amy Strange, Michelle Gardner, Coro Paisan-Ruiz, Gavin Band, Roger A. Barker, Celine Bellenguez, Kailash Bhatia, Hannah Blackburn, Jennie M. Blackwell, Elvira Bramon, Martin A. Brown, Matthew A. Brown, David Burn, Juan-Pablo Casas, Patrick F. Chinnery, Carl E. Clarke, Aiden Corvin, Nicholas Craddock, Panos Deloukas, Sarah Edkins, Jonathan Evans, Colin Freeman, Emma Gray, John Hardy, Gavin Hudson, Sarah Hunt, Janusz Jankowski, Cordelia Langford, Andrew J. Lees, Hugh S. Markus, Christopher G. Mathew, Mark I. McCarthy, Karen E. Morrison, Colin N.A. Palmer, Justin P. Pearson, Leena Peltonen, Matti Pirinen, Robert Plomin, Simon Potter, Anna Rautanen, Stephen J. Sawcer, Zhan Su, Richard C. Trembath, Ananth C. Viswanathan, Nigel W. Williams, Huw R. Morris, Peter Donnelly, Nicholas W. Wood |
| Abstract |
We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 French PD cases and 1984 controls for the 27 regions showing the strongest evidence of association (P< 10(-4)). We replicated published associations in the 4q22/SNCA and 17q21/MAPT chromosome regions (P< 10(-10)) and found evidence for an additional independent association in 4q22/SNCA. A detailed analysis of the haplotype structure at 17q21 showed that there are three separate risk groups within this region. We found weak but consistent evidence of association for common variants located in three previously published associated regions (4p15/BST1, 4p16/GAK and 1q32/PARK16). We found no support for the previously reported SNP association in 12q12/LRRK2. We also found an association of the two SNPs in 4q22/SNCA with the age of onset of the disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 209 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 3% |
| France | 1 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 196 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 23% |
| Researcher | 46 | 22% |
| Student > Master | 22 | 11% |
| Student > Bachelor | 21 | 10% |
| Professor | 14 | 7% |
| Other | 32 | 15% |
| Unknown | 25 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 24% |
| Biochemistry, Genetics and Molecular Biology | 38 | 18% |
| Medicine and Dentistry | 33 | 16% |
| Neuroscience | 22 | 11% |
| Computer Science | 6 | 3% |
| Other | 27 | 13% |
| Unknown | 33 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2024.
All research outputs
#1,968,990
of 23,510,717 outputs
Outputs from Human Molecular Genetics
#516
of 8,081 outputs
Outputs of similar age
#7,488
of 101,842 outputs
Outputs of similar age from Human Molecular Genetics
#5
of 58 outputs
Altmetric has tracked 23,510,717 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,081 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 101,842 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.