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Mendeley readers
Attention Score in Context
| Title |
Prothrombin Complex Concentrates for Oral Anticoagulant Therapy-Related Intracranial Hemorrhage: A Review of the Literature
|
|---|---|
| Published in |
Neurocritical Care, December 2009
|
| DOI | 10.1007/s12028-009-9310-0 |
| Pubmed ID | |
| Authors |
Eric M. Bershad, Jose I. Suarez |
| Abstract |
Warfarin-related intracranial hemorrhage carries a high mortality and poor neurological outcome. Rapid reversal of coagulopathy is a cornerstone of medical therapy to halt bleeding progression; however the optimal approach remains undefined. Prothrombin complex concentrates have promising features that may rapidly reverse coagulopathy, but remain relatively unstudied. We aim to review the literature regarding the use of prothrombin complex concentrates in patients with warfarin-related intracranial hemorrhage. A comprehensive review of the literature was conducted using PUBMED and Google Scholar databases to identify the use of PCC in patients with warfarin-related intracranial hemorrhage. The characteristics abstracted included the type of PCC, dosing, study design, type of intracranial hemorrhage, changes in the INR, and adverse effects. Prothrombin complex concentrates are heterogeneous in regards to factor concentration. PCC consistently reversed the INR in patients with intracranial hemorrhage. There is some evidence that PCC may reverse the INR more rapidly compared to fresh frozen plasma. Serious adverse effects were uncommon and included mainly thromboembolism. PCC has features which make it a promising therapy for patients with warfarin-related intracranial hemorrhage, and deserves more rigorous study in prospective-randomized controlled trials. |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Germany | 1 | 1% |
| Colombia | 1 | 1% |
| Denmark | 1 | 1% |
| Belgium | 1 | 1% |
| Unknown | 92 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 19% |
| Other | 14 | 14% |
| Student > Postgraduate | 10 | 10% |
| Professor > Associate Professor | 9 | 9% |
| Student > Master | 9 | 9% |
| Other | 25 | 26% |
| Unknown | 12 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 62 | 63% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Neuroscience | 3 | 3% |
| Chemical Engineering | 2 | 2% |
| Biochemistry, Genetics and Molecular Biology | 1 | 1% |
| Other | 7 | 7% |
| Unknown | 17 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2015.
All research outputs
#2,587,559
of 23,666,107 outputs
Outputs from Neurocritical Care
#220
of 1,556 outputs
Outputs of similar age
#12,808
of 168,957 outputs
Outputs of similar age from Neurocritical Care
#4
of 13 outputs
Altmetric has tracked 23,666,107 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,556 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,957 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.