@JacksonWheat1 @RedefineApolog1 https://t.co/tSpkTr1ZFp all humans carry many genetic variants predicted to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy in the human genome... genomes typically contain ~100 genuine
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@SmutClyde @Thatsregrettab1 @KlaasvanDijk5 Correct. The genome projects of our days show there is a net loss of function. https://t.co/yCUSoH7P7e
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We all have harmful genetic variants in our bodies. So fixing some of them is an appealing prospect. https://t.co/AL3HOp0tKk
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@SilverVVulpes @JayMan471 I would want to go for removal of loss-of-function variants. Though some harmful regulatory variants would probably be missed. We estimate that human genomes typically contain ~100 genuine LoF variants with ~20 genes completely i