Title |
Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study
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Published in |
European Journal of Epidemiology, March 2016
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DOI | 10.1007/s10654-016-0119-9 |
Pubmed ID | |
Authors |
Valentina Gallo, Nicola Vanacore, H. Bas Bueno-de-Mesquita, Roel Vermeulen, Carol Brayne, Neil Pearce, Petra A. Wark, Heather A. Ward, Pietro Ferrari, Mazda Jenab, Peter M. Andersen, Patrik Wennberg, Nicholas Wareham, Verena Katzke, Rudolf Kaaks, Elisabete Weiderpass, Petra H. Peeters, Amalia Mattiello, Valeria Pala, Aurelio Barricante, Maria-Dolores Chirlaque, Noémie Travier, Ruth C. Travis, Maria-Jose Sanchez, Hélène Pessah-Rasmussen, Jesper Petersson, Anne Tjønneland, Rosario Tumino, Jose Ramon Quiros, Antonia Trichopoulou, Andreas Kyrozis, Despoina Oikonomidou, Giovanna Masala, Carlotta Sacerdote, Larraitz Arriola, Heiner Boeing, Matthaeus Vigl, Francoise Claver-Chapelon, Lefkos Middleton, Elio Riboli, Paolo Vineis |
Abstract |
Previous case-control studies have suggested a possible increased risk of Amyotrophic Lateral Sclerosis (ALS) with physical activity (PA), but this association has never been studied in prospective cohort studies. We therefore assessed the association between PA and risk of death from ALS in the European Prospective Investigation into Cancer and Nutrition. A total of 472,100 individuals were included in the analysis, yielding 219 ALS deaths. At recruitment, information on PA was collected thorough standardised questionnaires. Total PA was expressed by the Cambridge Physical Activity Index (CPAI) and analysed in relation to ALS mortality, using Cox hazard models. Interactions with age, sex, and anthropometric measures were assessed. Total PA was weakly inversely associated with ALS mortality with a borderline statistically significant trend across categories (p = 0.042), with those physically active being 33 % less likely to die from ALS compared to those inactive: HR = 0.67 (95 % CI 0.42-1.06). Anthropometric measures, sex, and age did not modify the association with CPAI. The present study shows a slightly decreased-not increased like in case-control studies-risk of dying from ALS in those with high levels of total PA at enrolment. This association does not appear confounded by age, gender, anthropometry, smoking, and education. Ours was the first prospective cohort study on ALS and physical activity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 5 | 63% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 138 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 15% |
Student > Ph. D. Student | 20 | 14% |
Student > Bachelor | 17 | 12% |
Student > Master | 8 | 6% |
Student > Postgraduate | 7 | 5% |
Other | 25 | 18% |
Unknown | 40 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 23% |
Neuroscience | 12 | 9% |
Biochemistry, Genetics and Molecular Biology | 9 | 7% |
Nursing and Health Professions | 8 | 6% |
Agricultural and Biological Sciences | 5 | 4% |
Other | 24 | 17% |
Unknown | 48 | 35% |