Title |
Ferrocene-Modified Phospholipid: An Innovative Precursor for Redox-Triggered Drug Delivery Vesicles Selective to Cancer Cells
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Published in |
Langmuir, April 2016
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DOI | 10.1021/acs.langmuir.6b00511 |
Pubmed ID | |
Authors |
Tomer Noyhouzer, Chloé L’Homme, Isabelle Beaulieu, Stephanie Mazurkiewicz, Sabine Kuss, Heinz-Bernhard Kraatz, Sylvain Canesi, Janine Mauzeroll |
Abstract |
Controlled payload release is one of the key elements in the creation of a reliable drug delivery system. We report the discovery of a drug delivery vessel able to transport chemotherapeutic agents to target cancer cells and selectively trigger their release using the electrochemical activity of a ferrocene modified phospholipid. Supported by in vitro assays, the competitive advantages of this discovery are; i) the simple one step scalability of the synthetic process, ii) the stable encapsulation of toxic drugs (doxorubicin) during transport and iii) the selective redox triggering of the liposomes to harness their cytotoxic payload at the cancer site. Specifically the redox modified giant unilamellar vesicle and liposomes were characterized using advanced methods such as Scanning Electrochemical Microscopy (SECM), Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS) and fluorescent imaging. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 74 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 27% |
Researcher | 12 | 16% |
Student > Doctoral Student | 6 | 8% |
Student > Bachelor | 6 | 8% |
Student > Master | 5 | 7% |
Other | 9 | 12% |
Unknown | 16 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 33 | 45% |
Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Engineering | 3 | 4% |
Materials Science | 3 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 3 | 4% |
Unknown | 22 | 30% |