RT @SafiaDanovi: Newell et al perform a genomic landscape analysis of mucosal melanoma samples collected from three continents, suggesting…
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8/ These tumour are biologically different & do not commonly have the same mutations as their UV induced (skin) counterparts*, 9/eg ⬇️BRAF mutations, 10/ but they have same immunohistochemical profile *some UVR exposure was noted in some cases, but
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3/ They are thought to arise from resident melanocytes in this area. 4/ They have less mutations (compared with cutaneous tumours, which is due to UV radiation) and have a much higher number of rearrangements and amplifications. https://t.co/5ABjPg2pJI