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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension
|
|---|---|
| Published in |
Nature Communications, March 2016
|
| DOI | 10.1038/ncomms11082 |
| Pubmed ID | |
| Authors |
Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper |
| Abstract |
To maintain tissue integrity during epithelial morphogenesis, adherens junctions (AJs) must resist the mechanical stresses exerted by dynamic tissue movements. Junctional stability is dependent on actomyosin contractility within the actin ring. Here we describe a novel function for the axon guidance receptor, Neogenin, as a key component of the actin nucleation machinery governing junctional stability. Loss of Neogenin perturbs AJs and attenuates junctional tension. Neogenin promotes actin nucleation at AJs by recruiting the Wave regulatory complex (WRC) and Arp2/3. A direct interaction between the Neogenin WIRS domain and the WRC is crucial for the spatially restricted recruitment of the WRC to the junction. Thus, we provide the first example of a functional WIRS-WRC interaction in epithelia. We further show that Neogenin regulates cadherin recycling at the AJ. In summary, we identify Neogenin as a pivotal component of the AJ, where it influences both cadherin dynamics and junctional tension. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 62 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 30% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 8 | 13% |
| Researcher | 7 | 11% |
| Student > Postgraduate | 4 | 6% |
| Other | 9 | 14% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 21 | 33% |
| Agricultural and Biological Sciences | 18 | 29% |
| Neuroscience | 7 | 11% |
| Medicine and Dentistry | 3 | 5% |
| Chemistry | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 9 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2016.
All research outputs
#17,795,140
of 22,858,915 outputs
Outputs from Nature Communications
#43,304
of 47,073 outputs
Outputs of similar age
#206,338
of 301,001 outputs
Outputs of similar age from Nature Communications
#732
of 818 outputs
Altmetric has tracked 22,858,915 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 47,073 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,001 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 818 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.