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Mendeley readers
Attention Score in Context
| Title |
Brain Iron Metabolism Dysfunction in Parkinson’s Disease
|
|---|---|
| Published in |
Molecular Neurobiology, April 2016
|
| DOI | 10.1007/s12035-016-9879-1 |
| Pubmed ID | |
| Authors |
Hong Jiang, Jun Wang, Jack Rogers, Junxia Xie |
| Abstract |
Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's disease, and Huntington's disease. Understanding how iron accumulates in the substantia nigra (SN) and why it specifically targets dopaminergic (DAergic) neurons is particularly warranted for PD, as this knowledge may provide new therapeutic avenues for a more targeted neurotherapeutic strategy for this disease. In this review, we begin with a brief introduction describing brain iron metabolism and its regulation. We then provide a detailed description of how iron accumulates specifically in the SN and why DAergic neurons are especially vulnerable to iron in PD. Furthermore, we focus on the possible mechanisms involved in iron-induced cell death of DAergic neurons in the SN. Finally, we present evidence in support that iron chelation represents a plausable therapeutic strategy for PD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 147 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 30 | 20% |
| Student > Ph. D. Student | 26 | 17% |
| Student > Master | 23 | 15% |
| Researcher | 12 | 8% |
| Student > Doctoral Student | 5 | 3% |
| Other | 18 | 12% |
| Unknown | 35 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 21% |
| Neuroscience | 24 | 16% |
| Agricultural and Biological Sciences | 15 | 10% |
| Medicine and Dentistry | 11 | 7% |
| Chemistry | 9 | 6% |
| Other | 21 | 14% |
| Unknown | 38 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2018.
All research outputs
#1,774,049
of 22,860,626 outputs
Outputs from Molecular Neurobiology
#149
of 3,461 outputs
Outputs of similar age
#31,507
of 300,331 outputs
Outputs of similar age from Molecular Neurobiology
#4
of 114 outputs
Altmetric has tracked 22,860,626 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,461 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,331 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.