Title |
The gateway to transcription: identifying, characterizing and understanding promoters in the eukaryotic genome
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Published in |
Cellular and Molecular Life Sciences, December 2006
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DOI | 10.1007/s00018-006-6295-0 |
Pubmed ID | |
Authors |
N. D. Heintzman, B. Ren |
Abstract |
Eukaryotic transcriptional regulation requires the integration of complex signals by the transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications and coordinated protein-DNA interactions at these sequences constitute a transcriptional regulatory code that remains poorly understood today. Here, we review recent experimental and computational advances that have enabled the identification and analysis of transcriptional promoters on an unprecedented scale, laying a foundation for systematic determination of the transcriptional regulatory networks in eukaryotic cells. The knowledge gained from these large-scale investigations has challenged some conventional concepts of promoter structure and function, and provided valuable insights into the complex gene regulatory mechanisms in a variety of organisms. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
United Kingdom | 3 | 2% |
Germany | 2 | 1% |
Brazil | 2 | 1% |
Sweden | 1 | <1% |
Israel | 1 | <1% |
India | 1 | <1% |
France | 1 | <1% |
New Zealand | 1 | <1% |
Other | 3 | 2% |
Unknown | 161 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 53 | 29% |
Researcher | 39 | 22% |
Student > Master | 15 | 8% |
Professor | 15 | 8% |
Student > Doctoral Student | 12 | 7% |
Other | 30 | 17% |
Unknown | 16 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 92 | 51% |
Biochemistry, Genetics and Molecular Biology | 47 | 26% |
Medicine and Dentistry | 5 | 3% |
Computer Science | 5 | 3% |
Immunology and Microbiology | 2 | 1% |
Other | 9 | 5% |
Unknown | 20 | 11% |