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Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case–control study

Overview of attention for article published in European Journal of Clinical Microbiology & Infectious Diseases, March 2012
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Title
Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case–control study
Published in
European Journal of Clinical Microbiology & Infectious Diseases, March 2012
DOI 10.1007/s10096-012-1603-0
Pubmed ID
Authors

I. Vesteinsdottir, S. Gudlaugsdottir, R. Einarsdottir, E. Kalaitzakis, O. Sigurdardottir, E. S. Bjornsson

Abstract

Increased incidence and severity of Clostridium difficile infections (CDIs) is of major concern. However, by minimizing known risk factors, the incidence can be decreased. The aim of this investigation was to calculate the incidence and assess risk factors for CDI in our population. A 1-year prospective population-based nationwide study in Iceland of CDIs was carried out. For risk factor evaluation, each case was matched with two age- and sex-matched controls that tested negative for C. difficile toxin. A total of 128 CDIs were identified. The crude incidence was 54 cases annually per 100,000 population >18 years of age. Incidence increased exponentially with older age (319 per 100,000 population >86 years of age). Community-acquired origin was 27 %. Independent risk factors included: dicloxacillin (odds ratio [OR]: 7.55, 95 % confidence interval [CI]: 1.89-30.1), clindamycin (OR: 6.09, 95 % CI: 2.23-16.61), ceftriaxone (OR: 4.28, 95 % CI: 1.59-11.49), living in a retirement home (OR: 3.9, 95 % CI: 1.69-9.16), recent hospital stay (OR: 2.3, 95 % CI: 1.37-3.87). Proton pump inhibitors (PPIs) were used by 60/111 (54 %) versus 91/222 (41 %) (p = 0.026) and ciprofloxacin 19/111 (17 %) versus 19/222 (9 %) (p = 0.027) for cases and controls, respectively. In all, 75 % of primary CDIs treated with metronidazole recovered from one course of treatment. CDI was mostly found among elderly patients. The most commonly identified risk factors were broad-spectrum antibiotics and recent contact with health care institutions. PPI use was significantly more prevalent among CDI patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Chile 1 1%
Unknown 66 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 17%
Student > Bachelor 10 14%
Student > Ph. D. Student 8 12%
Student > Doctoral Student 6 9%
Student > Postgraduate 6 9%
Other 18 26%
Unknown 9 13%
Readers by discipline Count As %
Medicine and Dentistry 31 45%
Agricultural and Biological Sciences 4 6%
Immunology and Microbiology 4 6%
Nursing and Health Professions 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 9 13%
Unknown 15 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2014.
All research outputs
#20,296,832
of 24,953,268 outputs
Outputs from European Journal of Clinical Microbiology & Infectious Diseases
#2,329
of 2,956 outputs
Outputs of similar age
#129,116
of 165,280 outputs
Outputs of similar age from European Journal of Clinical Microbiology & Infectious Diseases
#22
of 24 outputs
Altmetric has tracked 24,953,268 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,956 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,280 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.