Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness https://t.co/L1LUAUlHFO
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GERMLINE: specific BRCA1/2 variants are differentially associated with different cancer types, forming clusters of breast and ovarian predisposition alleles. A prostate cancer cluster region has now been reported for BRCA2, overlapping a breast cluster. ht
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Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness https://t.co/ceQqBvUbxf
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"No genotype–phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer." https://t.co/58JzW0vwB6