@EMPoisonPharmD That said, I will disagree that there has not been human data. The proof-of-concept that fomepizole reduces oxidative metabolism in APAP has been demonstrated prospectively and impressively in (safely) poisoned human volunteers. https://
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RT @ebtapper: Acetaminophen causes liver damage when it is oxidized. NAC is a great antidote But is there a way to stop the oxidation?…
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RT @SteveCurryMD: Animal data also demonstrate 4MP's prevention of cJNK activation downstream from NAPQI formation & prevention of hepaotox…
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Animal data also demonstrate 4MP's prevention of cJNK activation downstream from NAPQI formation & prevention of hepaotoxicity when 4MP is given after oxidative metabolism complete. https://t.co/l7NyUloV7e