Title |
Compositional analysis of walnut lipid extracts and properties as an anti-cancer stem cell regulator via suppression of the self-renewal capacity
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Published in |
Food Science and Biotechnology, April 2016
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DOI | 10.1007/s10068-016-0087-6 |
Pubmed ID | |
Authors |
Jooyeon Chung, Yoo-Sun Kim, Jisoo Lee, Jae Hwan Lee, Sang-Woon Choi, Yuri Kim |
Abstract |
Colon cancer is a leading cause of cancer-related deaths worldwide. Effects of walnut (Juglans regia L.) lipid extracts (WLEs) on the self-renewal capacity of cancer stem cells (CSCs) in colon cancer were investigated. The dominant component of WLEs was α-linoleic acid (64.6%), followed by α-linolenic acid (14.6%), and oleic acid (12.6%). A higher concentration of γ-tocopherol (37.1%) was also present than of α-tocopherol (0.6%). CD133+CD44+CSCs treated with WLEs showed inhibition of colony formation and sphere formation, indicating a decrease in the self-renewal capacity. Treatment with WLEs also resulted in down-regulation of protein levels, including Notch1, phospho-GSK3β (p-GSK3β), and β-catenin, which are associated with CSCs and the self-renewing capacity. WLEs rich in essential fatty acids and γ-tocopherol can exert therapeutic actions on colon cancer via targeting of CSCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Iran, Islamic Republic of | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 32% |
Researcher | 3 | 16% |
Student > Doctoral Student | 2 | 11% |
Student > Master | 2 | 11% |
Professor | 2 | 11% |
Other | 3 | 16% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 21% |
Agricultural and Biological Sciences | 4 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Engineering | 2 | 11% |
Other | 2 | 11% |
Unknown | 3 | 16% |