a helyzet az, hogy mindenki az alapkutatásokban mutatott sikere alapján reménykedett a remdesivirben. ezek semennyire nem voltak ellentmondásosak. - https://t.co/NDxdWrugsR - https://t.co/zyHldEi1r0
ผมโพสต์ไว้ตั้งแต่แรกๆ ของการระบาด ก่อนที่คนส่วนใหญ่จะสนใจกันอีกว่า ยากลุ่ม #Remdesivir น่าจะเป็นยาที่ใช้ในการรักษาโรค #COVID19 นี้ . ลองไปดูโพสต์เก่าผมได้ตั้งแต่ช่วงมกราคม https://t.co/IvZJ4untoT . ตอนนี้เริ่มมีข่าวอัพเดตผลการรักษาของยานี้แล้ว . https://t
RT @DenisonLab: @timothysheahan @aetiology @MattFrieman @Baric_Lab @UNCResearch @UNCpublichealth Nice article with an important message! Wo…
RT @DenisonLab: @timothysheahan @aetiology @MattFrieman @Baric_Lab @UNCResearch @UNCpublichealth Nice article with an important message! Wo…
@timothysheahan @aetiology @MattFrieman @Baric_Lab @UNCResearch @UNCpublichealth Nice article with an important message! Would have been even better if it had also mentioned the outcome of your study comparing remdesivir with lopinavir & ritonavir agai
RT @HoLabHIV: @mattsiegel To my knowledge it has not been tested effective. Animal or at least cell culture studies like these may provide…
@mattsiegel To my knowledge it has not been tested effective. Animal or at least cell culture studies like these may provide scientific evidence for use of candidate drugs in humans: https://t.co/ZnSRv2jKbN https://t.co/SYf2rgeWKo
Comparative therapeutic efficacy of #remdesivir and combination #lopinavir, #ritonavir , and #interferon beta against MERS-CoV https://t.co/MPTstRL93e
RT @sciencecohen: I would have said that based on the remdesivir mouse data with SARS-CoV-1 and MERS. But with the understanding that it's…
I would have said that based on the remdesivir mouse data with SARS-CoV-1 and MERS. But with the understanding that it's experimental and may well not help. See: https://t.co/MdeozU9wAm and https://t.co/qQqDfQD3yY
Glad to see Dr Fauci was interested in #coronavirus January 10, 2020 and using #remdesivir for study in mice. Note to self: an #investment opportunity in the early stages with huge potential can come from the oddest mentions, if one was so inclined.
"we provide in vivo [in mice] evidence of the potential for #remdesivir to treat MERS-CoV infections." #covid19 Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir,and interferon beta against MERS-CoV Nature Communications
RT @mariagoneviral: While you're here, check out some of our work if you're interested! https://t.co/fDGBHqZNZn https://t.co/73WK7fEYQO ht…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. https://t.co/BD2cGQCB1S
Core Pubmed: Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.: Related Articles Comparative therapeutic efficacy of remdesivir and combination… https://t.co/JMqTgLUYX6 #coronavirus
#Covid19 De interés científico: https://t.co/9ykOGlPWIe
While @WHO can rely on some data to support trying HIV protease inhibitors, the by far most comprehensive study (from @Baric_Lab) I can find really calls this into question. https://t.co/MrVjbXg5uE
¿Y el medicamento Cubano? El interferón. Pues ese justamente se trabaja en combo con "lopinavir-ritonavir" ya se hicieron pruebas y en este artículo en Nature demuestran que no funcionan tan bien como el Remdesivir. https://t.co/wxJCC1cX8z
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
Encontrar un tratamiento eficaz frente a #COVID19 tiene doble función, tratar a enfermos y evitar que se infecte más gente. #Remdesivir, compuesto que "fracasó" frente al #Ebola tiene una segunda oportunidad frente a los coronavirus #MERS y #SARSCoV2 ht
re: kaletra
RT @HedgeyeHC: Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against ME… https:/…
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against ME… https://t.co/MPWzMutKBz
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
3. Anti Ebola remdesivir: mouse data only. https://t.co/zAZr1Hsr3S
RT @RobertLKruse: Failure somewhat predicted by MERS study in mice; Lopinavir–Ritonavir didn't work, while Remdisivir did https://t.co/QQ…
RT @timothysheahan: This is not surprising given that we (@Baric_Lab @DenisonLab) previously showed lopinavir/ritonavir was not very active…
RT @RobertLKruse: Failure somewhat predicted by MERS study in mice; Lopinavir–Ritonavir didn't work, while Remdisivir did https://t.co/QQ…
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
RT @FranciscoMarty_: @InfectiousDz @RamyRahme @onisillos @IDstewardship @IDSAInfo Take a look at this and other work from @Baric_Lab on in…
RT @timothysheahan: This is not surprising given that we (@Baric_Lab @DenisonLab) previously showed lopinavir/ritonavir was not very active…
RT @timothysheahan: This is not surprising given that we (@Baric_Lab @DenisonLab) previously showed lopinavir/ritonavir was not very active…
Linking the paper here https://t.co/dfwFI6TgAV
RT @timothysheahan: This is not surprising given that we (@Baric_Lab @DenisonLab) previously showed lopinavir/ritonavir was not very active…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @FranciscoMarty_: @djvanness @InfectiousDz @onisillos @IDstewardship @IDSAInfo Hard to push this further when there is little signal in…
Failure somewhat predicted by MERS study in mice; Lopinavir–Ritonavir didn't work, while Remdisivir did https://t.co/QQmIv8Emtg That said, severe patients were treated in the study, and it's likely that it might only work early in infection if at all ht
@dittmannlab @FranciscoMarty_ @InfectiousDz @onisillos @IDstewardship @IDSAInfo We show very weak antiviral effect (~1/2 log) in mice and only with prophylactic lopinavir/ritonavir. We coupled that with IFNb because that was what was in trial in KSA for ME
RT @timothysheahan: This is not surprising given that we (@Baric_Lab @DenisonLab) previously showed lopinavir/ritonavir was not very active…
This is not surprising given that we (@Baric_Lab @DenisonLab) previously showed lopinavir/ritonavir was not very active against #MERS in vitro and did not improve outcomes in vivo. #coroanvirus #antivirals https://t.co/ZcWUKDPhwr
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
In mice prophylactic and therapeutic RDV improve pulmonary function, reduce lung VL and severe lung path Prophylactic LPV/RTV-IFNb slightly reduces VLw/o impacting other disease parameters Rx LPV/RTV-IFNb improves pulmonary function but not virus repl+path
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
@InfectiousDz @RamyRahme @onisillos @IDstewardship @IDSAInfo Take a look at this and other work from @Baric_Lab on in vitro and animal activity for MERS, similar to SARS: https://t.co/LU3WNDx3vK
RT @FranciscoMarty_: @djvanness @InfectiousDz @onisillos @IDstewardship @IDSAInfo Hard to push this further when there is little signal in…
@djvanness @InfectiousDz @onisillos @IDstewardship @IDSAInfo Hard to push this further when there is little signal in vitro and animal models, see @Baric_Lab’s work including: https://t.co/8DqG1jfzhd
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
RT @MayoClinicINFD: 6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate…
6/ #Remdesevir A nucleotide-analog inhibitor of RNA-dependent RNA polymerases Clinical: anecdotal only Compassionate use - contact company Enrol in clinical trials https://t.co/dj1zYQnk68
RT @NatureComms: Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
@__ice9 Ok, my claim, chloroquine doesn't work with SARS in vivo, doesn't work with plenty of virus in vivo/RCT despite in vitro result. Lopinavir/ritonavir seem to work far worse than remdesivir for MERS https://t.co/DWvtIS21Ws
Algunas lecturas importantes: https://t.co/wLrI2VKgRo https://t.co/r9BvGQ5XOA https://t.co/uUhhsCMPJW Uno de ellos fue escrito en la University of Alberta 🥰
@RCAFDM @BioBreakout In mice, remdesivir looked a bit better against MERS, but both improved clinical parameters. Perhaps related to differences in protein binding of the drug in the bloodstream-- difficult to be certain. Lopinavir-ritonavir was formulat
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @StefanoPPK: Πες τους να στραφούν στο Remdesivir που είναι πιο αποτελεσματικό. Το "κουβανικό φάρμακο" μειώνει το ιικό φορτίο χωρίς να επ…
RT @StefanoPPK: Πες τους να στραφούν στο Remdesivir που είναι πιο αποτελεσματικό. Το "κουβανικό φάρμακο" μειώνει το ιικό φορτίο χωρίς να επ…
RT @StefanoPPK: Πες τους να στραφούν στο Remdesivir που είναι πιο αποτελεσματικό. Το "κουβανικό φάρμακο" μειώνει το ιικό φορτίο χωρίς να επ…
Πες τους να στραφούν στο Remdesivir που είναι πιο αποτελεσματικό. Το "κουβανικό φάρμακο" μειώνει το ιικό φορτίο χωρίς να επηρεάζει παραμέτρους όπως η βλάβη στους πνεύμονες (Sheahan study: https://t.co/wu3i4tai4L). Και μη γράφεις αριστερίστικες βλακείες για
RT @a_chtung: https://t.co/bUa2VSbIfC тестирование на MERS-CoV: сравните эффективность ремдесивира (IC50=0,09 мкМ) и лопинавира/ритонавира…
https://t.co/bUa2VSbIfC тестирование на MERS-CoV: сравните эффективность ремдесивира (IC50=0,09 мкМ) и лопинавира/ритонавира (IC50=8,5 мкМ): https://t.co/AnpqmJcU6e
RT @nicomedbxl: #kaletra (lopinavir/r) is inferior to #remdesivir both in vivo & in vitro models of #MERSCov https://t.co/zLXCnCGF9o
RT @nicomedbxl: #kaletra (lopinavir/r) is inferior to #remdesivir both in vivo & in vitro models of #MERSCov https://t.co/zLXCnCGF9o
RT @nicomedbxl: #kaletra (lopinavir/r) is inferior to #remdesivir both in vivo & in vitro models of #MERSCov https://t.co/zLXCnCGF9o
@vijayasankarv I’ve recently seen similar studies showing same or similar treatments helping target HIV (and other CoVs like MERS). They work by blocking an enzyme these viruses need to mature & reduce their pulmonary pathologies. https://t.co/F8D7WWv
RT @nicomedbxl: #kaletra (lopinavir/r) is inferior to #remdesivir both in vivo & in vitro models of #MERSCov https://t.co/zLXCnCGF9o
In una comparazione scientifica il farmaco sperimentale #remdesivir risulta più efficace delle combinazioni ritonavir, lopinavir e interferone beta. Introducetelo velocemente come cura primaria nei protocolli #COVID19 #curacovid19 #COVID2019italia https:/
RT @brainartec: Does Remdesivir help against MERS-CoV? https://t.co/SMAK4iDqV6 #coronavirus #gileadsciences #ICYMI
Does Remdesivir help against MERS-CoV? https://t.co/SMAK4iDqV6 #coronavirus #gileadsciences #ICYMI
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @CarlosdelRio7: In mice model remedesivir + INFb superior to LPV/r against MERS-CoV | @NatureComms https://t.co/QAnOCkNNOS
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV | Nature Communications https://t.co/ypR46U27wF
Remdesivir: um antiviral promissor contra os coronavírus O sucesso do remdesivir em vários modelos animais com infecção por MERS-CoV pode lançar as bases para o tratamento de casos graves de COVID-19. https://t.co/I66T3hNEmQ https://t.co/MQ381vnMns htt
@C1aranMurray These numbers probably cut in half at least (or more) with proper treatment. (Extreme extrapolation from remdesivir data in MERS-CoV) https://t.co/h54hVHEyJM
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV | Nature Communications #COVID19 #CoronavirusOutbreak https://t.co/66KQiDi6C4
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @timothysheahan: Our timely new pub on a broad-spectrum antiviral for emerging coronavirus. Took a village @DenisonLab @Baric_Lab @Sarah…
RT @Sciguy999: A timely @NatureComms paper from the Baric lab in MICE. Comparative therapeutic efficacy of remdesivir & combination lopinav…