Title |
Stem cells in ectodermal development
|
---|---|
Published in |
Journal of Molecular Medicine, May 2012
|
DOI | 10.1007/s00109-012-0908-x |
Pubmed ID | |
Authors |
Salvador Aznar Benitah, Michaela Frye |
Abstract |
Tissue-specific stem cells sustain organs for a lifetime through self-renewal and generating differentiated progeny. Although tissue stem cells are established during organogenesis, the precise origin of most adult stem cells in the developing embryo is unclear. Mammalian skin is one of the best-studied epithelial systems containing stem cells to date, however the origin of most of the stem cell populations found in the adult epidermis is unknown. Here, we try to recapitulate the emergence and genesis of an ectodermal stem cell during development until the formation of an adult skin. We ask whether skin stem cells share key transcriptional regulators with their embryonic counterparts and discuss whether embryonic-like stem cells may persist through to adulthood in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Nepal | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 23% |
Student > Bachelor | 11 | 19% |
Student > Ph. D. Student | 11 | 19% |
Student > Master | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 6 | 11% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 32% |
Biochemistry, Genetics and Molecular Biology | 13 | 23% |
Medicine and Dentistry | 5 | 9% |
Neuroscience | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 9% |
Unknown | 13 | 23% |