Title |
Potential of Coffee Fruit Extract and Quinic Acid on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes.
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Published in |
Kobe journal of medical sciences, October 2018
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Pubmed ID | |
Authors |
Acharaporn Duangjai, Nitra Nuengchamnong, Nungruthai Suphrom, Kanittaporn Trisat, Nanteetip Limpeanchob, Surasak Saokaew |
Abstract |
This study was to assess the impact of different colors of coffee fruit (green, yellow and red) on adipogenesis and/or lipolysis using 3T3-L1 adipocytes. Characterization of chemical constituents in different colors of coffee fruit extracts was determined by ESI-Q-TOF-MS. The cytotoxicity of the extracts in 3T3-L1 preadipocytes were evaluated by MTT assay. Oil-red O staining and amount of glycerol released in 3T3-L1 adipocytes were measured for lipid accumulation and lipolysis activity. All coffee fruit extracts displayed similar chromatographic profiles by chlorogenic acid > caffeoylquinic acid > caffeic acid. Different colors of raw coffee fruit possessed inhibitory adipogenesis activity in 3T3-L1 adipocytes, especially CRD decreased lipid accumulation approximately 47%. Furthermore, all extracts except CYF and their major compounds (malic, quinic, and chlorogenic acid) increased glycerol release. Our data suggest that different colors of coffee fruit extract have possessed anti-adipogenic and lipolytic properties and may contribute to the anti-obesity effects. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
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Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 17% |
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Other | 2 | 5% |
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Immunology and Microbiology | 1 | 2% |
Other | 3 | 7% |
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