G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

Overview of attention for article published in Diabetologia, July 2012

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RT @bcellorg: Great talk @mvandebunt1 !! Interesting re: the DAG pathway. This is the downstream mechanism for GPR40 https://t.co/8h6wotpZwa

Great talk @mvandebunt1 !! Interesting re: the DAG pathway. This is the downstream mechanism for GPR40 https://t.co/8h6wotpZwa

GPR40アゴニストによるGSIS増強メカニズム。オレイン酸は単離膵島でGPR40を介しGSIS第二相・Fアクチン再構成・PKDリン酸化を増強。DAG添加によるGSIS増強はGPR40を介さず。オレイン酸誘導GSIS増強はPKD阻害で消失。http://t.co/NPH1oGoJ

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