Title |
Chronic Recurrent Multifocal Q Fever Osteomyelitis in Children
|
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Published in |
The Pediatric Infectious Disease Journal, September 2016
|
DOI | 10.1097/inf.0000000000001211 |
Pubmed ID | |
Authors |
Joshua R. Francis, Jennifer Robson, David Wong, Mark Walsh, Ivan Astori, David Gill, Clare Nourse |
Abstract |
Clinical disease caused by Coxiella burnetii occurs infrequently in children. Chronic Q fever is particularly uncommon and endocarditis is rarely seen. A small number of cases of Q fever osteomyelitis have been described but the pathophysiology is not well understood and optimal treatment is unknown. We describe a series of cases of chronic recurrent multifocal Q fever osteomyelitis cases diagnosed in children from a single region in Australia. Between 2011 and 2014, 9 cases of chronic recurrent multifocal Q fever osteomyelitis were diagnosed based on clinical findings, suggestive serology and detection of Coxiella burnetii DNA by polymerase chain reaction testing of biopsy samples (8/9). All required surgical management; antibiotic and adjuvant therapies did not appear to be consistently effective and 2 cases had clinical resolution in the absence of directed antimicrobial therapy. Chronic recurrent multifocal osteomyelitis is a rare manifestation of chronic Q fever infection in children. The pathophysiology of this condition is poorly understood, and effective treatment options have not been established. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 20% |
Professor > Associate Professor | 3 | 12% |
Student > Master | 3 | 12% |
Other | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 5 | 20% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 44% |
Immunology and Microbiology | 2 | 8% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 2 | 8% |
Unknown | 7 | 28% |