Title |
Stearidonic Acid‐Enriched Soybean Oil Increased the Omega‐3 Index, an Emerging Cardiovascular Risk Marker
|
---|---|
Published in |
Lipids, August 2008
|
DOI | 10.1007/s11745-008-3215-0 |
Pubmed ID | |
Authors |
William S. Harris, Shawna L. Lemke, Susan N. Hansen, Daniel A. Goldstein, Maureen A. DiRienzo, Hong Su, Margaret A. Nemeth, Mary L. Taylor, Gulam Ahmed, Cherian George |
Abstract |
A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA+DHA levels (the omega-3 index). Overweight healthy volunteers (n=45) were randomized to SDA-SBO (24 ml/day providing approximately 3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (approximately 1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p<0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Spain | 1 | 1% |
Netherlands | 1 | 1% |
France | 1 | 1% |
Unknown | 80 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 22 | 26% |
Student > Ph. D. Student | 11 | 13% |
Student > Master | 10 | 12% |
Other | 7 | 8% |
Student > Bachelor | 6 | 7% |
Other | 15 | 18% |
Unknown | 14 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 29% |
Medicine and Dentistry | 14 | 16% |
Biochemistry, Genetics and Molecular Biology | 6 | 7% |
Nursing and Health Professions | 5 | 6% |
Chemistry | 5 | 6% |
Other | 14 | 16% |
Unknown | 16 | 19% |