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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives
|
|---|---|
| Published in |
Journal of Natural Medicines, July 2016
|
| DOI | 10.1007/s11418-016-1020-2 |
| Pubmed ID | |
| Authors |
Megan M. Marlow, Sumedh S. Shah, Eduardo A. Véliz, Michael E. Ivan, Regina M. Graham |
| Abstract |
Resistance mechanisms employed by high-grade gliomas allow them to successfully evade current standard treatment of chemotherapy and radiation treatment. Withaferin A (WA), utilized in Ayurvedic medicine for centuries, is attracting attention for its antitumor capabilities. Here we review pertinent literature on WA as a high-grade glioma treatment, and discuss the cancerous mechanisms it affects. WA is relatively nontoxic and has shown potential in crossing the blood-brain barrier. WA prevents p53 alterations and inactivates overexpressed MDM2 through ARF and ROS production. Furthermore, WA upregulates Bax, inducing mitochondrial death cascades, inhibits mutated Akt, mTOR, and NF-κB pathways, and inhibits angiogenesis in tumors. Therapy with WA for high-grade gliomas is supported through the literature. Further investigation is warranted and encouraged to fully unearth its abilities against malignant gliomas. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Portugal | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 22% |
| Professor > Associate Professor | 5 | 14% |
| Other | 4 | 11% |
| Researcher | 4 | 11% |
| Student > Doctoral Student | 2 | 6% |
| Other | 7 | 19% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 42% |
| Agricultural and Biological Sciences | 5 | 14% |
| Neuroscience | 3 | 8% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Psychology | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 7 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2017.
All research outputs
#19,942,887
of 25,371,288 outputs
Outputs from Journal of Natural Medicines
#326
of 571 outputs
Outputs of similar age
#267,287
of 366,065 outputs
Outputs of similar age from Journal of Natural Medicines
#6
of 10 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 571 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 366,065 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.