Title |
Association between Change in Normal Appearing White Matter Metabolites and Intrathecal Inflammation in Natalizumab-Treated Multiple Sclerosis
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Published in |
PLOS ONE, September 2012
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DOI | 10.1371/journal.pone.0044739 |
Pubmed ID | |
Authors |
Johan Mellergård, Anders Tisell, Olof Dahlqvist Leinhard, Ida Blystad, Anne-Marie Landtblom, Kaj Blennow, Bob Olsson, Charlotte Dahle, Jan Ernerudh, Peter Lundberg, Magnus Vrethem |
Abstract |
Multiple sclerosis (MS) is associated not only with focal inflammatory lesions but also diffuse pathology in the central nervous system (CNS). Since there is no firm association between the amount of focal inflammatory lesions and disease severity, diffuse pathology in normal appearing white matter (NAWM) may be crucial for disease progression. Immunomodulating treatments for MS reduce the number of focal lesions, but possible effects on diffuse white matter pathology are less studied. Furthermore, it is not known whether intrathecal levels of inflammatory or neurodegenerative markers are associated with development of pathology in NAWM. |
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Mendeley readers
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