Title |
Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats
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Published in |
BMC Neuroscience, September 2012
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DOI | 10.1186/1471-2202-13-109 |
Pubmed ID | |
Authors |
Toktam Hajjar, Goh Y Meng, Mohamed A Rajion, Sharmili Vidyadaran, Fauziah Othman, Abdoreza S Farjam, Tan A Li, Mahdi Ebrahimi |
Abstract |
This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague-Dawley rats were randomly allotted into 3 groups of ten animals each and received experimental diets with different n-6: n-3 PUFA ratios of either 65:1, 22:1 or 4.5:1. After 10 weeks, the spatial memory of the animals was assessed using the Morris Water Maze test. The expression of PPARα and PPARγ genes were determined using real-time PCR. |
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