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Chronic pistachio intake modulates circulating microRNAs related to glucose metabolism and insulin resistance in prediabetic subjects

Overview of attention for article published in European Journal of Nutrition, July 2016
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Title
Chronic pistachio intake modulates circulating microRNAs related to glucose metabolism and insulin resistance in prediabetic subjects
Published in
European Journal of Nutrition, July 2016
DOI 10.1007/s00394-016-1262-5
Pubmed ID
Authors

Pablo Hernández-Alonso, Simona Giardina, Jordi Salas-Salvadó, Pierre Arcelin, Mònica Bulló

Abstract

To assess the effects of a pistachio-enriched diet on the profile of circulating microRNAs (miRNAs) related to glucose metabolism and insulin resistance (IR). Randomized crossover clinical trial in 49 subjects with prediabetes was performed. Subjects consumed a pistachio-supplemented diet (PD, 50 % carbohydrates, 33 % fat, including 57 g/day of pistachios) and an isocaloric control diet (CD, 55 % carbohydrates and 30 % fat) for 4 months each, separated by a 2-week washout period. The plasma profile of a set of seven predefined miRNAs related to glucose and insulin metabolism was analyzed by quantitative RT-PCR. After the PD period, subjects have shown significant lower circulating levels of miR-192 and miR-375 compared to CD period, whereas miR-21 nonsignificantly increased after PD compared with CD (47 vs. 2 %, P = 0.092). Interestingly, changes in circulating miR-192 and miR-375 were positively correlated with plasma glucose, insulin and HOMA-IR. Chronic pistachio consumption positively modulates the expression of some miRNA previously implicated on insulin sensitivity.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 98 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 15%
Student > Ph. D. Student 15 15%
Student > Bachelor 12 12%
Student > Master 11 11%
Professor 5 5%
Other 13 13%
Unknown 27 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 17%
Medicine and Dentistry 16 16%
Agricultural and Biological Sciences 10 10%
Nursing and Health Professions 7 7%
Social Sciences 4 4%
Other 12 12%
Unknown 32 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2022.
All research outputs
#13,864,183
of 22,663,969 outputs
Outputs from European Journal of Nutrition
#1,537
of 2,377 outputs
Outputs of similar age
#198,631
of 355,043 outputs
Outputs of similar age from European Journal of Nutrition
#25
of 51 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,377 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.9. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,043 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.