Title |
Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
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Published in |
Anais da Academia Brasileira de Ciências, May 2015
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DOI | 10.1590/0001-3765201520140063 |
Pubmed ID | |
Authors |
Ahmad Reza Gohari, Mahmoud Mosaddegh, Farzaneh Naghibi, Bahara Eslami-Tehrani, Atefeh Pirani, Maryam Hamzeloo-Moghadam, Roger W. Read |
Abstract |
Inula aucheriana DC is a member of the family Asteraceae which is known to produce cytotoxic secondary metabolites noted as sesquiterpene lactones. In the present study, sesquiterpene lactones inuchinenolide B, 6-deoxychamissonolide (stevin) and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were isolated from I. aucheriana. Inuchinenolide B and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were further evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to demonstrate cytotoxic activity with IC50 values of (56.6, 19.0), (39.0, 11.8), and (55.7, 15.3) μg/mL against HepG-2, MCF-7 and A-549 cells, respectively. The cytotoxic activity of the two evaluated sesquiterpene lactones partly explains the cytotoxic activity that was previously observed for the extracts of Inula aucheriana. The isolated compounds could be further investigated in cancer research studies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 14% |
Student > Bachelor | 3 | 14% |
Lecturer | 2 | 10% |
Other | 2 | 10% |
Professor > Associate Professor | 2 | 10% |
Other | 5 | 24% |
Unknown | 4 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 14% |
Chemistry | 3 | 14% |
Agricultural and Biological Sciences | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Other | 2 | 10% |
Unknown | 5 | 24% |