Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality

Overview of attention for article published in European Heart Journal, March 2021

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@neelroop CRP definitely not causal. For NLRP3 there is this article reporting an intronic variant that influences expression and as a result downstream signaling, which was associated with coronary artery disease and cardiovascular mortality https://…

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation & CVS mortality. Functional relevance of single-nucleotide polymorphisms on NLRP3 inflammasome activtn in monocyte-enriched peripheral blood mononuclear cell …

@ShihchengGuo https://t.co/5h5DNi2ZZg

🔗link to the paper providing some genetic evidence: https://t.co/5h5DNi2ZZg

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