AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss

Overview of attention for article published in European Journal of Medicinal Chemistry, September 2021

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CDK2 degraders, mostly VHL. Appears to have selectivity within the CDK family. Potency could use some optimization (Dmax ~50%). Some in vivo data via a zebrafish model; interpretation complicated due to decrease in b-actin normalization signal. https://…

RT @Trankill34: AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss https://t.co/9HZr…

AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss https://t.co/9HZrlVFm1x

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