E-cadherin loss in Cd44-positive gastric cells initiates diffuse gastric cancer in a murine model

Overview of attention for article published in Gut, February 2026

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Latest publication from Otago Biochemistry. E-cadherin loss in Cd44-positive gastric cells initiates diffuse gastric cancer in a murine model gut.bmj.com/content/earl...

🐁 Scientists developed mouse models of sporadic and hereditary diffuse gastric cancer (DGC) by inactivation of Cdh1 in the stomach. They generated tamoxifen-inducible Cre/loxP models of DGC driven by the Cd44 promoter with a tdTomato reporter. https://…

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