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Mendeley readers
Attention Score in Context
| Title |
Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro
|
|---|---|
| Published in |
Cancer Research, December 2006
|
| DOI | 10.1158/0008-5472.can-06-2066 |
| Pubmed ID | |
| Authors |
Meredith T. Morgan, Yuka Nakanishi, David J. Kroll, Aaron P. Griset, Michael A. Carnahan, Michel Wathier, Nicholas H. Oberlies, Govindarajan Manikumar, Mansukh C. Wani, Mark W. Grinstaff |
| Abstract |
A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and 7-butyl-10-aminocamptothecin. The cytotoxicity of the dendrimer-drug complex toward four different human cancer cell lines [human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (HT-29), non-small cell lung carcinoma (NCI-H460), and glioblastoma (SF-268)] is also reported, and low nmol/L IC(50) values are measured. Cellular uptake and efflux measurements in MCF-7 cells show an increase of 16-fold for cellular uptake and an increase in drug retention within the cell when using the dendrimer vehicle. |
Mendeley readers
The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 3 | 2% |
| Russia | 1 | <1% |
| Denmark | 1 | <1% |
| Egypt | 1 | <1% |
| Unknown | 181 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 27% |
| Student > Master | 30 | 16% |
| Researcher | 27 | 14% |
| Student > Bachelor | 19 | 10% |
| Professor > Associate Professor | 9 | 5% |
| Other | 21 | 11% |
| Unknown | 30 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 51 | 27% |
| Agricultural and Biological Sciences | 30 | 16% |
| Biochemistry, Genetics and Molecular Biology | 14 | 7% |
| Engineering | 13 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 7% |
| Other | 35 | 19% |
| Unknown | 31 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2022.
All research outputs
#4,695,422
of 22,785,242 outputs
Outputs from Cancer Research
#4,601
of 17,867 outputs
Outputs of similar age
#20,978
of 156,190 outputs
Outputs of similar age from Cancer Research
#43
of 165 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,867 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,190 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.