Retinal Degenerative Diseases

Table of Contents

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   Book Overview
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   Chapter 1 Oxidative Stress Regulation and DJ-1 Function in the Retinal Pigment Epithelium: Implications for AMD
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   Chapter 2 Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration
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   Chapter 3 Toll-Like Receptors and Age-Related Macular Degeneration
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   Chapter 4 Alterations in Extracellular Matrix/Bruch’s Membrane Can Cause the Activation of the Alternative Complement Pathway via Tick-Over
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   Chapter 5 MicroRNA as Therapeutics for Age-Related Macular Degeneration
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   Chapter 6 Anaphylatoxin Signaling in Retinal Pigment and Choroidal Endothelial Cells: Characteristics and Relevance to Age-Related Macular Degeneration
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   Chapter 7 Estimations of Retinal Blue-Light Irradiance Values and Melatonin Suppression Indices Through Clear and Yellow-Tinted Intraocular Lenses
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   Chapter 8 Co-Expression of Wild-Type and Mutant S163R C1QTNF5 in Retinal Pigment Epithelium
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    Chapter 9 Mini-Review: Cell Type-Specific Optogenetic Vision Restoration Approaches
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    Chapter 10 Mutation-Independent Gene Therapies for Rod-Cone Dystrophies
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    Chapter 11 Antisense Oligonucleotide-Based Splice Correction of a Deep-Intronic Mutation in CHM Underlying Choroideremia
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    Chapter 12 Gene Therapy Approaches to Treat the Neurodegeneration and Visual Failure in Neuronal Ceroid Lipofuscinoses
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    Chapter 13 Success of Gene Therapy in Late-Stage Treatment
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    Chapter 14 Optimizing Non-viral Gene Therapy Vectors for Delivery to Photoreceptors and Retinal Pigment Epithelial Cells
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    Chapter 15 Nanoparticles as Delivery Vehicles for the Treatment of Retinal Degenerative Diseases
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    Chapter 16 Overexpression of Type 3 Iodothyronine Deiodinase Reduces Cone Death in the Leber Congenital Amaurosis Model Mice
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    Chapter 17 In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators
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    Chapter 18 Optimizing ERG Measures of Scotopic and Photopic Critical Flicker Frequency
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    Chapter 19 Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina
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    Chapter 20 Normative Retinal Thicknesses in Common Animal Models of Eye Disease Using Spectral Domain Optical Coherence Tomography
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    Chapter 21 A Novel Approach for Integrating AF-SLO and SDOCT Imaging Data Demonstrates the Ability to Identify Early Retinal Abnormalities in Mutant Mice and Evaluate the Effects of Genetic and Pharmacological Manipulation
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    Chapter 22 The Role of Hypoxia, Hypoxia-Inducible Factor (HIF), and VEGF in Retinal Angiomatous Proliferation
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    Chapter 23 Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview
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    Chapter 24 Autoimmune Retinopathy: An Immunologic Cellular-Driven Disorder
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    Chapter 25 Inflammation-Induced Photoreceptor Cell Death
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    Chapter 26 Sall1 Regulates Microglial Morphology Cell Autonomously in the Developing Retina
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    Chapter 27 Whole-Exome Sequencing Identifies Novel Variants that Co-segregates with Autosomal Recessive Retinal Degeneration in a Pakistani Pedigree
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    Chapter 28 Identification of Novel Deletions as the Underlying Cause of Retinal Degeneration in Two Pedigrees
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    Chapter 29 Molecular Findings in Families with an Initial Diagnose of Autosomal Dominant Retinitis Pigmentosa (adRP)
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    Chapter 30 Pleiotropic Effects of Risk Factors in Age-Related Macular Degeneration and Seemingly Unrelated Complex Diseases
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    Chapter 31 Mapping of Canine Models of Inherited Retinal Diseases
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    Chapter 32 A Mini-Review: Leber Congenital Amaurosis: Identification of Disease-Causing Variants and Personalised Therapies
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    Chapter 33 Role of Fibulins 2 and 5 in Retinal Development and Maintenance
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    Chapter 34 Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice
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    Chapter 35 How Excessive cGMP Impacts Metabolic Proteins in Retinas at the Onset of Degeneration
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    Chapter 36 Protein Carbonylation-Dependent Photoreceptor Cell Death Induced by N-Methyl-N-nitrosourea in Mice
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    Chapter 37 Müller Glia Reactivity and Development of Gliosis in Response to Pathological Conditions
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    Chapter 38 Underdeveloped RPE Apical Domain Underlies Lesion Formation in Canine Bestrophinopathies
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    Chapter 39 Binary Function of ARL3-GTP Revealed by Gene Knockouts
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    Chapter 40 Do cGMP Levels Drive the Speed of Photoreceptor Degeneration?
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    Chapter 41 Early Endosome Morphology in Health and Disease
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    Chapter 42 The Retinal Circadian Clock and Photoreceptor Viability
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    Chapter 43 The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss
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    Chapter 44 The Evaluation of BMI1 Posttranslational Modifications During Retinal Degeneration to Understand BMI1 Action on Photoreceptor Death Execution
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    Chapter 45 Primary Rod and Cone Degeneration Is Prevented by HDAC Inhibition
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    Chapter 46 Impact of MCT1 Haploinsufficiency on the Mouse Retina
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    Chapter 47 The Leber Congenital Amaurosis-Linked Protein AIPL1 and Its Critical Role in Photoreceptors
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    Chapter 48 Alternative Splicing for Activation of Coagulation Factor XIII-A in the Fish Retina After Optic Nerve Injury
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    Chapter 49 Bisretinoid Photodegradation Is Likely Not a Good Thing
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    Chapter 50 Further Characterization of the Predominant Inner Retinal Degeneration of Aging Cln3 Δex7/8 Knock-In Mice
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    Chapter 51 Differential Exon Expression in a Large Family of Retinal Genes Is Regulated by a Single Trans Locus
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    Chapter 52 Molecular Chaperone ERp29: A Potential Target for Cellular Protection in Retinal and Neurodegenerative Diseases
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    Chapter 53 The Role of Microbiota in Retinal Disease
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    Chapter 54 Current Pharmacological Concepts in the Treatment of the Retinitis Pigmentosa
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    Chapter 55 Valproic Acid Inhibits Human Retinal Pigment Epithelial (hRPE) Cell Proliferation Via a P38 MAPK Signaling Mechanism
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    Chapter 56 Pigment Epithelium-derived Factor Protects Retinal Pigment Epithelial Cells Against Cytotoxicity “In Vitro”
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    Chapter 57 Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration
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    Chapter 58 VEGF as a Trophic Factor for Müller Glia in Hypoxic Retinal Diseases
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    Chapter 59 Müller Cell Biological Processes Associated with Leukemia Inhibitory Factor Expression
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    Chapter 60 Retbindin Is Capable of Protecting Photoreceptors from Flavin-Sensitized Light-Mediated Cell Death In Vitro
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    Chapter 61 Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice
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    Chapter 62 Maintaining Cone Function in Rod-Cone Dystrophies
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    Chapter 63 PKG-Dependent Cell Death in 661W Cone Photoreceptor-like Cell Cultures (Experimental Study)
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    Chapter 64 More Than Meets the Eye: Current Understanding of RPGR Function
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    Chapter 65 Polarized Exosome Release from the Retinal Pigmented Epithelium
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    Chapter 66 The Impact of Adherens and Tight Junctions on Physiological Function and Pathological Changes in the Retina
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    Chapter 67 TRPV4 Does Not Regulate the Distal Retinal Light Response
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    Chapter 68 Role of Sirtuins in Retinal Function Under Basal Conditions
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    Chapter 69 The Retinol-Binding Protein Receptor 2 (Rbpr2) Is Required for Photoreceptor Survival and Visual Function in the Zebrafish
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    Chapter 70 Opposite Roles of MerTK Ligands Gas6 and Protein S During Retinal Phagocytosis
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    Chapter 71 Redundant and Nonredundant Functions of Akt Isoforms in the Retina
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    Chapter 72 Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay
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    Chapter 73 Preservation of Photoreceptor Nanostructure for Electron Tomography Using Transcardiac Perfusion Followed by High-Pressure Freezing and Freeze-Substitution
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    Chapter 74 Microtubule-Associated Protein 1 Light Chain 3 (LC3) Isoforms in RPE and Retina
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    Chapter 75 The iPSc-Derived Retinal Tissue as a Tool to Study Growth Factor Production in the Eye
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    Chapter 76 Stem Cell-Based RPE Therapy for Retinal Diseases: Engineering 3D Tissues Amenable for Regenerative Medicine
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    Chapter 77 Validation of iPS Cell-Derived RPE Tissue in Animal Models
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    Chapter 78 Cell Transplantation for Retinal Degeneration: Transition from Rodent to Nonhuman Primate Models
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    Chapter 79 Talaumidin Promotes Neurite Outgrowth of Staurosporine-Differentiated RGC-5 Cells Through PI3K/Akt-Dependent Pathways