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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses
|
|---|---|
| Published in |
Cell Reports, August 2015
|
| DOI | 10.1016/j.celrep.2015.07.040 |
| Pubmed ID | |
| Authors |
Casandra Panea, Adam M. Farkas, Yoshiyuki Goto, Shahla Abdollahi-Roodsaz, Carolyn Lee, Balázs Koscsó, Kavitha Gowda, Tobias M. Hohl, Milena Bogunovic, Ivaylo I. Ivanov |
| Abstract |
Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute to the generation of CD4 T cell responses to intestinal microbes is unclear. Th17 cells are critical for mucosal immune protection and at steady state are induced by commensal bacteria, such as segmented filamentous bacteria (SFB). Here, we examined the roles of mucosal DCs and Mfs in Th17 induction by SFB in vivo. We show that Mfs, and not conventional CD103(+) DCs, are essential for the generation of SFB-specific Th17 responses. Thus, Mfs drive mucosal T cell responses to certain commensal bacteria. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 25% |
| Saudi Arabia | 1 | 13% |
| United States | 1 | 13% |
| Unknown | 4 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Scientists | 2 | 25% |
| Science communicators (journalists, bloggers, editors) | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 192 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 187 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 27% |
| Researcher | 38 | 20% |
| Student > Master | 18 | 9% |
| Student > Bachelor | 18 | 9% |
| Student > Doctoral Student | 15 | 8% |
| Other | 21 | 11% |
| Unknown | 31 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 62 | 32% |
| Agricultural and Biological Sciences | 45 | 23% |
| Medicine and Dentistry | 23 | 12% |
| Biochemistry, Genetics and Molecular Biology | 16 | 8% |
| Economics, Econometrics and Finance | 3 | 2% |
| Other | 11 | 6% |
| Unknown | 32 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2016.
All research outputs
#7,896,932
of 25,374,917 outputs
Outputs from Cell Reports
#9,980
of 12,960 outputs
Outputs of similar age
#85,454
of 276,169 outputs
Outputs of similar age from Cell Reports
#148
of 204 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 12,960 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,169 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 204 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.