β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

RT @manruipa: (17/17) Main sources continued: - Early biological markers of post-acute sequelae of SARS-CoV-2 infection https://t.co/6eV6…

(17/17) Main sources continued: - Early biological markers of post-acute sequelae of SARS-CoV-2 infection https://t.co/ig0OhaBuBE - Multiple early factors anticipate post-acute COVID-19 sequelae https://t.co/1PoZw8ABwC - Diverse functional autoantib…

@hoahhe @zev_dr Excellent question. Check what Dr Altan - Bonnet (NIH. Oct 2020)said about prevention of De-acidification of lysosomes in our cells with the help of intra cellular Zinc. https://t.co/k5NR8hkY3M

@ejustin46 This paper directly challenged the older “Golgi secretory exit” dogma. https://t.co/lK329ZNEIz

SARS-2 exiting via hijacked lysosomes. Glad my memory of this was not hallucinated...@LongDesertTrain Not sure if science has moved on from this early understanding, though? Need to ASKaVIROLOGIST(TM) @SolidEvidence https://t.co/OMH7MMTqVE

RT @Leo238umi: ① Lysosomal egress Lysosome acidification is required for its enzymatic stability & activity, and even a small increase in…

@mkeulemans @VelzenRemco @volkskrant Enerzijds maakt HCQ lysosomen onklaar https://t.co/M2h4FS7Uf1 Handig tegen kankercellen, minder handig wanneer je ze nodig hebt bij het antigen-presentatie proces aan de buitenkant van de cel. Anderzijds mis/gebruikt…

@MathieuMolimard @afpfr @APMinfos @SFPT_fr @ansm @olivierveran @Sante_Gouv https://t.co/lK329ZOcy7

RT @Jerichon_kat: β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway https://t.co/xo8Z6jS8FL

備忘分泌経路 https://t.co/1yzTfie65q

cc: .@carl_jurassic .@Fynnderella1

RT @Leo238umi: ② Lysosomal egress “Such non-lytic release of β-CoVs results in lysosome deacidification, inactivation of lysosomal degrada…

RT @Leo238umi: ① Lysosomal egress Lysosome acidification is required for its enzymatic stability & activity, and even a small increase in…

RT @zzz_as_zzz: SARS-Cov-2 affects acidity of lysosome and autophagocytosis, potentially preparing for the amyloid flower? Beta Cov Egres…

SARS-Cov-2 affects acidity of lysosome and autophagocytosis, potentially preparing for the amyloid flower? Beta Cov Egress https://t.co/o4FURt5tzl Coronavirus Usurps the Autophagy-Lysosome Pathway https://t.co/SJb1BGLb2C Flower theory https://t.co/…

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic S... https://t.co/QAIjSneD3O

https://t.co/xkunINp7yw

RT @fdzaraf: - β-コロナウイルスは, 生合成分泌経路の代わりに排出にリソソームを使用することが報告されている(図, https://t.co/gWDIIfvrU8)。 - リソソームには, スフィンゴミエリンとコレステロールが含まれているが, エンベロープにはこ…

- β-コロナウイルスは, 生合成分泌経路の代わりに排出にリソソームを使用することが報告されている(図, https://t.co/gWDIIfvrU8)。 - リソソームには, スフィンゴミエリンとコレステロールが含まれているが, エンベロープにはこれらが含まれていないことから, リソソームは…

RT @zzz_as_zzz: 新型コロナウイルスを含むベータ・コロナウイルスが、細胞から出る時にリソゾームを使うという論文。先月チラっと見たのですが、昨日読んだら重要な話が沢山。 https://t.co/09t5HHKtqs https://t.co/l39o5PJh…

RT @ChristosArgyrop: @hjelle_brian @PansyDowanger @DFisman It does not burst cells open either , just crapped out through the lysosomes, so…

@ENirenberg @notdred @MarkELindsay @Neurofourier I tried to ask Leonardi that earlier today bc there’s clearly problems with immunosuppression. But…..I’m not completely against an overactive T cell response contribution in some cases. T cells seem to be s…

Follow up

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway - PubMed. https://t.co/haKKEuuEOy

@MarrietTheSpy @profpathogen1 https://t.co/S0RNsJvZCc

@MarrietTheSpy https://t.co/S0RNsJvZCc

@JSAHolmes @barryjohnreid21 @JustPlaying2Win @Bebert701 @NateWeymouth @newcarlton @andylumm @carlsmythe @ADevotedYogi @lizditz @ChrisJohnsonMD @MdRisette @pawley_robert @SassyGirlD1 @wjack76995 @BurgerLab12 @kfunk937 @mcfunny @TierraHenson @L1ND4K @Bill…

@Laurie_Garrett @Merck @Regeneron I think your diagram is sketchy, if not misleading. Please see: https://t.co/IU573l9kdo

@ENirenberg @wanderer_jasnah @ProfPCDoherty MHV affects lysosomal degradation since beta coronaviruses can use lysosomes for egress. That's how MHC-I presentation might be affected if you provide all viral components in an inactivated vaccine (presumabl…

@Parsifaler Non-lytic viruses are nothing new. It only proves what you think it proves if you're trapped in confirmation bias. Learn some virology & some critical reasoning skills. The latter will serve you immensely in life. https://t.co/Ip5rKB…

@HuetSylvestre Pas mal faux. Le virus ne pénetre pas au niveau de la membrane plasmique mais apres endocytose. Le virus n'est pas assemblé dans le Golgi mais dans des lysosomes specialisés https://t.co/guVBbauxY2

@Undergroundsar3 That is certainly true, however, the lysosome would be deacidified, rendering many of its enzymes inactive. https://t.co/KicomTxt1D

RRIDs were included in the Cell paper "β-Coronaviruses Use Lysosomes for Egress Instead o…" (https://t.co/w01U9NsT3m). Thank you for making your #methodsmatter. #accelerateopenscience

RT @wanderer_jasnah: @LauringLab @deeptabhattacha @SCOTTeHENSLEY egress for β-CoVs is lysosomal: https://t.co/nvWxcuyqdU (basically, traffi…

RT @mmw_lmw: β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway | Nihal Altan-Bonnet @NIH @CellCellPres…

Lysosomes por egress instead of the biosynthetic secretory pathway

RT @mmw_lmw: β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway | Nihal Altan-Bonnet @NIH @CellCellPres…

β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway | Nihal Altan-Bonnet @NIH @CellCellPress https://t.co/Ebawydzbta | #2020_ReCapOct https://t.co/OX8u6ZIZBJ

RT @AfghaniHani: #معلومة_تهم_الباحثين... تمكن علماء #الأحياء_الجزيئية و #التقنية_الحيوية من تحديد مسار إفرازي جديد ومختلف ل #فيروس_كورونا ن…

#معلومة_تهم_الباحثين... تمكن علماء #الأحياء_الجزيئية و #التقنية_الحيوية من تحديد مسار إفرازي جديد ومختلف ل #فيروس_كورونا نوع بيتا حيث يستخدم الليزوزومات للخروج بدلا من الإفراز الحيوي التقليدي مما يجعل طريقة العدوى وأيضا العلاج أكثر فهما ومساعدا... الرابط…

@HarmitMalik @RalserLab It doesn't look like that's happening though - here's a preprint that got SLAMMED in one of its open reviews (https://t.co/INgnN9bHXa) only to make it out a couple months later in Cell! (https://t.co/M5jvOiiO1M).

https://t.co/LLZtjDFFVR Sarscov-2 etc infection => "Lysosomes are deacidified, and proteolytic enzymes are inactive Antigen processing and presentation are perturbed" β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pat…

RT @CellCellPress: #βCoronaviruses use lysosomal #organelles for cellular egress. Out now! @nih_nhlbi @NIH https://t.co/0ecKb47HfT https://…

https://t.co/7krdwJeGyh

https://t.co/1Av6WpTz2b

https://t.co/AojawjcSAh

RT @CellCellPress: #βCoronaviruses use lysosomal #organelles for cellular egress. Out now! @nih_nhlbi @NIH https://t.co/0ecKb47HfT https://…

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway https://t.co/xo8Z6jS8FL

RT @CellCellPress: #βCoronaviruses use lysosomal #organelles for cellular egress. Out now! @nih_nhlbi @NIH https://t.co/0ecKb47HfT https://…

Very interesting paper showing that β-coronaviruses egress from infected cells by tracking a path through deacidified lysosomal organelles. https://t.co/vMXpea9DF1

β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

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