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| Title |
Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia
|
|---|---|
| Published in |
Anais da Academia Brasileira de Ciências, August 2015
|
| DOI | 10.1590/0001-3765201520140714 |
| Pubmed ID | |
| Authors |
ALEXANDRA I. ZUGNO, LARA CANEVER, GUSTAVO MASTELLA, ALEXANDRA S. HEYLMANN, MARIANA B. OLIVEIRA, AMANDA V. STECKERT, ADALBERTO A. CASTRO, FELIPE DAL PIZZOL, JOÃO QUEVEDO, CLARISSA S. GAMA |
| Abstract |
New studies suggest that polyunsaturated fatty acids, such as omega-3, may reduce the symptoms of schizophrenia. The present study evaluated the preventive effect of omega-3 on interleukines (IL) and neurotrophin brain-derived neurotrophic factor (BDNF) levels in the brains of young rats subjected to a model of schizophrenia. Treatment was performed over 21 days, starting on the 30th day of rat's life. After 14 days of treatment with omega-3 or vehicle, a concomitant treatment with saline or ketamine (25 mg/kg) was started and maintained until the last day of the experiment. BDNF levels in the rat's prefrontal cortex were decreased at 1 h and 24 h after the last administration of ketamine, whereas the group administered with ketamine and omega-3 showed a decrease in BDNF levels only after 24 h. In contrast, both interventions induced similar responses in levels of IL-1β and IL6. These findings suggest that the similarity of IL-1β and IL6 levels in our experimental groups is due to the mechanism of action of ketamine on the immune system. More studies have to be carried out to explain this pathology. In conclusion, according to previous studies and considering the current study, we could suggest a prophylactic role of omega-3 against the outcome of symptoms associated with schizophrenia. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 16% |
| Researcher | 7 | 14% |
| Student > Bachelor | 6 | 12% |
| Student > Master | 4 | 8% |
| Lecturer > Senior Lecturer | 3 | 6% |
| Other | 11 | 22% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
| Medicine and Dentistry | 5 | 10% |
| Psychology | 3 | 6% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 9 | 18% |
| Unknown | 16 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2016.
All research outputs
#23,320,957
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Outputs from Anais da Academia Brasileira de Ciências
#3
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#237,837
of 277,646 outputs
Outputs of similar age from Anais da Academia Brasileira de Ciências
#3
of 3 outputs
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