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Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia

Overview of attention for article published in Anais da Academia Brasileira de Ciências, August 2015
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Title
Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia
Published in
Anais da Academia Brasileira de Ciências, August 2015
DOI 10.1590/0001-3765201520140714
Pubmed ID
Authors

ALEXANDRA I. ZUGNO, LARA CANEVER, GUSTAVO MASTELLA, ALEXANDRA S. HEYLMANN, MARIANA B. OLIVEIRA, AMANDA V. STECKERT, ADALBERTO A. CASTRO, FELIPE DAL PIZZOL, JOÃO QUEVEDO, CLARISSA S. GAMA

Abstract

New studies suggest that polyunsaturated fatty acids, such as omega-3, may reduce the symptoms of schizophrenia. The present study evaluated the preventive effect of omega-3 on interleukines (IL) and neurotrophin brain-derived neurotrophic factor (BDNF) levels in the brains of young rats subjected to a model of schizophrenia. Treatment was performed over 21 days, starting on the 30th day of rat's life. After 14 days of treatment with omega-3 or vehicle, a concomitant treatment with saline or ketamine (25 mg/kg) was started and maintained until the last day of the experiment. BDNF levels in the rat's prefrontal cortex were decreased at 1 h and 24 h after the last administration of ketamine, whereas the group administered with ketamine and omega-3 showed a decrease in BDNF levels only after 24 h. In contrast, both interventions induced similar responses in levels of IL-1β and IL6. These findings suggest that the similarity of IL-1β and IL6 levels in our experimental groups is due to the mechanism of action of ketamine on the immune system. More studies have to be carried out to explain this pathology. In conclusion, according to previous studies and considering the current study, we could suggest a prophylactic role of omega-3 against the outcome of symptoms associated with schizophrenia.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 14%
Researcher 6 14%
Student > Bachelor 6 14%
Student > Master 4 9%
Other 3 7%
Other 9 21%
Unknown 9 21%
Readers by discipline Count As %
Neuroscience 7 16%
Medicine and Dentistry 6 14%
Psychology 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Agricultural and Biological Sciences 2 5%
Other 9 21%
Unknown 14 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2016.
All research outputs
#9,963,550
of 12,446,028 outputs
Outputs from Anais da Academia Brasileira de Ciências
#158
of 318 outputs
Outputs of similar age
#169,702
of 247,134 outputs
Outputs of similar age from Anais da Academia Brasileira de Ciências
#1
of 1 outputs
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