Title |
Low glycemic index diet reduces body fat and attenuates inflammatory and metabolic responses in patients with type 2 diabetes
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Published in |
Archives of Endocrinology and Metabolism, September 2016
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DOI | 10.1590/2359-3997000000206 |
Pubmed ID | |
Authors |
Júnia Maria Geraldo Gomes, Sabrina Pinheiro Fabrini, Rita de Cássia Gonçalves Alfenas |
Abstract |
The aim of this study was to verify the effects of glycemic index (GI) on body composition, and on inflammatory and metabolic markers concentrations in patients with type 2 diabetes. In this randomized controlled parallel trial, twenty subjects (aged 42.4 ± 5.1 years, BMI 29.2 ± 4.8 kg.m-2) were allocated to low GI (LGI) (n = 10) or high GI (HGI) (n = 10) groups. Body composition, inflammatory and metabolic markers were assessed at baseline and after 30 days of intervention. Food intake was monitored during the study using three-day food records completed on two non-consecutive weekdays and on a weekend day. Body fat reduced after the LGI intervention compared with baseline (P = 0.043) and with the HGI group (P = 0.036). Serum fructosamine concentration (P = 0.031) and TNF-α mRNA expression (P = 0.05) increased in the HGI group. Serum non-esterified fatty acids were greater in the HGI than in the LGI group (P = 0.032). IL-6 mRNA expression tended to decrease after the consumption of the LGI diet compared to baseline (P = 0.06). The LGI diet reduced body fat and prevented the negative metabolic and inflammatory responses induced by the HGI diet. |
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United States | 9 | 41% |
United Kingdom | 1 | 5% |
Sweden | 1 | 5% |
South Africa | 1 | 5% |
Australia | 1 | 5% |
Chile | 1 | 5% |
Unknown | 8 | 36% |
Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 5 | 23% |
Scientists | 3 | 14% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 29 | 23% |
Student > Master | 20 | 16% |
Researcher | 10 | 8% |
Student > Doctoral Student | 8 | 6% |
Student > Postgraduate | 7 | 6% |
Other | 16 | 13% |
Unknown | 37 | 29% |
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Medicine and Dentistry | 25 | 20% |
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Agricultural and Biological Sciences | 7 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 12 | 9% |
Unknown | 43 | 34% |